PMID- 26854840
OWN - NLM
STAT- MEDLINE
DCOM- 20170317
LR  - 20171116
IS  - 1557-9077 (Electronic)
IS  - 1050-7256 (Linking)
VI  - 26
IP  - 4
DP  - 2016 Apr
TI  - Oxidative Stress and Advanced Glycation End Products in Hashimoto's Thyroiditis.
PG  - 504-11
LID - 10.1089/thy.2015.0592 [doi]
AB  - BACKGROUND: Oxidative stress, which occurs as a result of an imbalance between 
      free-radical production and antioxidant defense mechanisms, has been implicated 
      in the pathogenesis of several autoimmune disorders, including thyroid diseases. 
      Importantly, it has been correlated to thyroid dysfunction. This study 
      investigated the changes in oxidative balance in euthyroid Hashimoto's 
      thyroiditis (HT) by means of specific serum tests, such as derived reactive 
      oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP) test. 
      In addition, advanced glycation end products (AGEs) and advanced oxidation 
      protein products (AOPPs)--compounds formed by the transformation of 
      proteins--were evaluated as potential new markers of oxidative stress in this 
      disease. METHODS: This study included 134 euthyroid subject: 71 newly diagnosed 
      HT patients (63 females; M age = 38 +/- 13 years) and 63 age and sex-matched 
      healthy controls. None of them were on thyroxine therapy. RESULTS: Serum d-ROMs 
      were elevated, and BAP decreased in HT patients compared with controls (p < 
      0.001), and the two parameters were inversely correlated (r = -0.211; p = 0.027), 
      clearly indicating an enhanced oxidative stress. Furthermore, AGE levels were 
      higher in HT patients (M = 223.18 AU/g prot) than in controls (M = 189.636 AU/g 
      prot; p = 0.020) and inversely correlated with BAP levels (r = -0.196; p = 
      0.037). In uni- and multivariate analysis, serum antithyroperoxidase antibodies 
      were the main predictors for d-ROMs (p = 0.006), BAP (p < 0.001), and AGEs (p = 
      0.014), irrespective of thyrotropin and/or free thyroxine values. No differences 
      in AOPPs levels were found between patients and controls (p = 0.923). 
      CONCLUSIONS: Oxidants are increased and antioxidants decreased in euthyroid HT 
      patients. As a result, the oxidative/antioxidative balance is shifted toward the 
      oxidative side. Moreover, this study reports on a possible significant 
      involvement of AGEs in HT, thus contributing to a better definition of the redox 
      homoeostasis dysregulation in HT.
FAU - Ruggeri, Rosaria M
AU  - Ruggeri RM
AD  - 1 Department of Clinical and Experimental Medicine, Division of Endocrinology, 
      University of Messina , Messina, Italy .
FAU - Vicchio, Teresa M
AU  - Vicchio TM
AD  - 1 Department of Clinical and Experimental Medicine, Division of Endocrinology, 
      University of Messina , Messina, Italy .
FAU - Cristani, Mariateresa
AU  - Cristani M
AD  - 2 Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of 
      Messina , Messina, Italy .
FAU - Certo, Rosaria
AU  - Certo R
AD  - 1 Department of Clinical and Experimental Medicine, Division of Endocrinology, 
      University of Messina , Messina, Italy .
FAU - Caccamo, Daniela
AU  - Caccamo D
AD  - 3 Department of Biomedical Sciences and Morpho-Functional Imaging, University of 
      Messina , Messina, Italy .
FAU - Alibrandi, Angela
AU  - Alibrandi A
AD  - 4 Department of Economics, University of Messina , Messina, Italy .
FAU - Giovinazzo, Salvatore
AU  - Giovinazzo S
AD  - 1 Department of Clinical and Experimental Medicine, Division of Endocrinology, 
      University of Messina , Messina, Italy .
FAU - Saija, Antonina
AU  - Saija A
AD  - 2 Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of 
      Messina , Messina, Italy .
FAU - Campenni, Alfredo
AU  - Campenni A
AD  - 3 Department of Biomedical Sciences and Morpho-Functional Imaging, University of 
      Messina , Messina, Italy .
FAU - Trimarchi, Francesco
AU  - Trimarchi F
AD  - 1 Department of Clinical and Experimental Medicine, Division of Endocrinology, 
      University of Messina , Messina, Italy .
AD  - 5 Accademia Peloritana dei Pericolanti, University of Messina , Messina, Italy .
FAU - Gangemi, Sebastiano
AU  - Gangemi S
AD  - 6 School and Division of Allergy and Clinical Immunology, Department of Clinical 
      and Experimental Medicine, University of Messina , Messina, Italy .
LA  - eng
PT  - Journal Article
DEP - 20160309
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Antioxidants)
RN  - 0 (Biomarkers)
RN  - 0 (Free Radicals)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Oxidants)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Adult
MH  - Antioxidants/chemistry
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Free Radicals
MH  - Glycation End Products, Advanced/*blood
MH  - Hashimoto Disease/*blood
MH  - Homeostasis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxidants/chemistry
MH  - Oxidation-Reduction
MH  - *Oxidative Stress
MH  - Oxygen/chemistry
MH  - Thyroid Gland/pathology
MH  - Thyrotropin/blood
MH  - Thyroxine/therapeutic use
MH  - Ultrasonography
EDAT- 2016/02/09 06:00
MHDA- 2017/03/18 06:00
CRDT- 2016/02/09 06:00
PHST- 2016/02/09 06:00 [entrez]
PHST- 2016/02/09 06:00 [pubmed]
PHST- 2017/03/18 06:00 [medline]
AID - 10.1089/thy.2015.0592 [doi]
PST - ppublish
SO  - Thyroid. 2016 Apr;26(4):504-11. doi: 10.1089/thy.2015.0592. Epub 2016 Mar 9.