PMID- 26855490
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160209
LR  - 20220716
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 31
IP  - 1
DP  - 2016 Mar
TI  - Tumor Necrosis Factor-Alpha, Interleukin-6, C-Reactive Protein Levels and Insulin 
      Resistance Associated with Type 2 Diabetes in Abdominal Obesity Women.
PG  - 68-74
LID - 10.1007/s12291-015-0514-0 [doi]
AB  - We aim to investigate the association between elevated tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-6 (IL-6) and high sensitivity-C-reactive protein (hs-CRP) 
      with type 2 diabetes mellitus (T2DM) in abdominal obesity (AO) women subjects. A 
      total of 428 AO subjects (age 48.4 +/- 10.2 years), and 107 non-AO women subjects 
      (age 48.8 +/- 11.8 years) were enrolled for the all biochemistry testing, 
      inflammatory cytokines, fasting insulin and Homeostasis Model Assessment of 
      insulin resistance (HOMA-IR). Body mass index, waist circumference (WC), blood 
      pressure (BP), plasma glucose (Glu), triglyceride (TG), insulin, HOMA-IR and 
      inflammatory cytokines were significantly higher and lower total antioxidant 
      capacity, HDL-C in AO subjects (p < 0.05). WC was significantly correlated with 
      BP, Glu, TG, LDL-C, insulin, HOMA-IR, TNF-alpha, IL-6 and negative correlation with 
      HDL-C in AO subjects. Elevation of TNF-alpha, IL-6, hs-CRP and insulin resistance 
      were significantly associated with T2DM in AO subjects, after adjusting with 
      insulin resistance, increased oxidative stress, elevated TG and reduced HDL-C by 
      using multiple logistic regression analysis. In conclusions, elevation of 
      inflammatory cytokines, oxidative stress and insulin resistance were associated 
      with T2DM in AO women subjects. These inflammatory cytokines are positively 
      associated with T2DM and may have a causal relation with an increased oxidative 
      stress and insulin resistance in these AO women subjects.
FAU - Tangvarasittichai, Surapon
AU  - Tangvarasittichai S
AD  - Chronic Diseases Research Unit, Department of Medical Technology, Faculty of 
      Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand.
FAU - Pongthaisong, Suthap
AU  - Pongthaisong S
AD  - SaiNgam District Public Health Office, Ministry of Public Health, Kumpangphet, 
      62150 Thailand.
FAU - Tangvarasittichai, Orathai
AU  - Tangvarasittichai O
AD  - Chronic Diseases Research Unit, Department of Medical Technology, Faculty of 
      Allied Health Sciences, Naresuan University, Phitsanulok, 65000 Thailand.
LA  - eng
PT  - Journal Article
DEP - 20150726
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC4731374
OTO - NOTNLM
OT  - Abdominal obesity
OT  - Insulin resistance
OT  - Interleukin-6
OT  - Tumor necrosis factor- alpha
OT  - Type 2 diabetes mellitus
OT  - hs-CRP
EDAT- 2016/02/09 06:00
MHDA- 2016/02/09 06:01
PMCR- 2017/03/01
CRDT- 2016/02/09 06:00
PHST- 2014/11/06 00:00 [received]
PHST- 2015/07/08 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2016/02/09 06:00 [entrez]
PHST- 2016/02/09 06:00 [pubmed]
PHST- 2016/02/09 06:01 [medline]
AID - 514 [pii]
AID - 10.1007/s12291-015-0514-0 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2016 Mar;31(1):68-74. doi: 10.1007/s12291-015-0514-0. Epub 
      2015 Jul 26.