PMID- 26855492
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160209
LR  - 20220716
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 31
IP  - 1
DP  - 2016 Mar
TI  - Hypoxia-Induced Inflammatory Chemokines in Subjects with a History of 
      High-Altitude Pulmonary Edema.
PG  - 81-6
LID - 10.1007/s12291-015-0491-3 [doi]
AB  - High altitude hypoxia is known to induce an inflammatory response in immune 
      cells. Hypoxia induced inflammatory chemokines may contribute to the development 
      of high altitude pulmonary edema (HAPE) by causing damage to the lung endothelial 
      cells and thereby capillary leakage. In the present study, we were interested to 
      know whether chronic inflammation may contribute to HAPE susceptibility. We 
      examined the serum levels of macrophage inflammatory protein-1alpha (MIP-1alpha), 
      monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 in group (1) HAPE 
      Susceptible subjects (n = 20) who had past history of HAPE and group (2) Control 
      (n = 18) consist of subjects who had stayed at high altitude for 2 years without 
      any history of HAPE. The data obtained confirmed that circulating MCP-1, MIP-1alpha 
      were significantly upregulated in HAPE-S individuals as compared to the controls 
      suggestive of chronic inflammation. However, it is not certain whether chronic 
      inflammation is cause or consequence of previous episode of HAPE. The moderate 
      systemic increase of these inflammatory markers may reflect considerable local 
      inflammation. The existence of enhanced level of inflammatory chemokines found in 
      this study support the hypothesis that subjects with past history of HAPE have 
      higher baseline chronic inflammation which may contribute to HAPE susceptibility.
FAU - Mishra, K P
AU  - Mishra KP
AD  - Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, 
      Lucknow Road, Timarpur, Delhi, 110054 India.
FAU - Sharma, Navita
AU  - Sharma N
AD  - Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, 
      Lucknow Road, Timarpur, Delhi, 110054 India.
FAU - Soree, Poonam
AU  - Soree P
AD  - Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, 
      Lucknow Road, Timarpur, Delhi, 110054 India.
FAU - Gupta, R K
AU  - Gupta RK
AD  - Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, 
      Lucknow Road, Timarpur, Delhi, 110054 India.
FAU - Ganju, Lilly
AU  - Ganju L
AD  - Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, 
      Lucknow Road, Timarpur, Delhi, 110054 India.
FAU - Singh, S B
AU  - Singh SB
AD  - Immunomodulation Laboratory, Defence Institute of Physiology & Allied Sciences, 
      Lucknow Road, Timarpur, Delhi, 110054 India.
LA  - eng
PT  - Journal Article
DEP - 20150314
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC4731363
OTO - NOTNLM
OT  - AMS
OT  - Chemokines
OT  - HAPE
OT  - Inflammation
OT  - SpO2
EDAT- 2016/02/09 06:00
MHDA- 2016/02/09 06:01
PMCR- 2017/03/01
CRDT- 2016/02/09 06:00
PHST- 2015/01/14 00:00 [received]
PHST- 2015/02/27 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2016/02/09 06:00 [entrez]
PHST- 2016/02/09 06:00 [pubmed]
PHST- 2016/02/09 06:01 [medline]
AID - 491 [pii]
AID - 10.1007/s12291-015-0491-3 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2016 Mar;31(1):81-6. doi: 10.1007/s12291-015-0491-3. Epub 
      2015 Mar 14.