PMID- 26855511
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160209
LR  - 20200930
IS  - 0971-4502 (Print)
IS  - 0974-0449 (Electronic)
IS  - 0971-4502 (Linking)
VI  - 32
IP  - 1
DP  - 2016 Mar
TI  - A Prospective Study of Adequacy of Anticoagulation with Fixed Dose Weight 
      Adjusted Unfractionated Heparin in Patients with Deep Vein Thrombosis.
PG  - 83-6
LID - 10.1007/s12288-015-0563-9 [doi]
AB  - Weight adjusted fixed dose subcutaneous unfractionated heparin (UFH) is one of 
      the options for the treatment of deep vein thrombosis (DVT), but the degree of 
      its anticoagulant effect has not been tested in India. This was a prospective 
      observational study, conducted at a tertiary care hospital in South India between 
      September 2012 and March 2014. DVT was diagnosed using compression 
      ultrasonography. UFH was given as an initial loading dose of 333 U/kg followed by 
      a maintenance dose of 250 U/kg twice daily subcutaneously. aPTT was done on day 2 
      and day 4 after 6 h of the morning dose of heparin. Patients were categorized 
      based on aPTT ratios. Fifty five patients treated for proximal lower limb DVT had 
      received UFH. Their median age was 41 years. DVT was secondary to malignancy, 
      immobilisation or pro-coagulant state. No obvious etiology was found in 47 % of 
      the patients. The mean aPTT on day 2 was 41.8 s and 51.7 s on day 4. The aPTT 
      ratio was subtherapeutic in 63.6 % and therapeutic in 32.7 % of the patients on 
      day 2. Five patients had adverse events in the hospital. Three patients died and 
      two other patients had confirmed pulmonary embolism. Death was due to pulmonary 
      embolism in one patient and metastatic malignancies in the other two. No bleeding 
      manifestation had occurred. Caution is required in implementing this UFH regimen 
      as this preliminary investigation has found predominantly subtherapeutic aPTT 
      ratios during the initial phase of anticoagulation.
FAU - Bose, Subash Chandra
AU  - Bose SC
AD  - Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Puducherry, 605006 India.
FAU - Kar, Rakhee
AU  - Kar R
AD  - Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Puducherry, 605006 India.
FAU - Shamanna, Suryanarayana Bettadpura
AU  - Shamanna SB
AD  - Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Puducherry, 605006 India.
LA  - eng
PT  - Journal Article
DEP - 20150708
PL  - India
TA  - Indian J Hematol Blood Transfus
JT  - Indian journal of hematology & blood transfusion : an official journal of Indian 
      Society of Hematology and Blood Transfusion
JID - 9425818
PMC - PMC4733679
OTO - NOTNLM
OT  - Anticoagulation
OT  - Deep vein thrombosis
OT  - Pulmonary embolism
OT  - Unfractionated heparin
EDAT- 2016/02/09 06:00
MHDA- 2016/02/09 06:01
PMCR- 2017/03/01
CRDT- 2016/02/09 06:00
PHST- 2015/02/23 00:00 [received]
PHST- 2015/06/16 00:00 [accepted]
PHST- 2017/03/01 00:00 [pmc-release]
PHST- 2016/02/09 06:00 [entrez]
PHST- 2016/02/09 06:00 [pubmed]
PHST- 2016/02/09 06:01 [medline]
AID - 563 [pii]
AID - 10.1007/s12288-015-0563-9 [doi]
PST - ppublish
SO  - Indian J Hematol Blood Transfus. 2016 Mar;32(1):83-6. doi: 
      10.1007/s12288-015-0563-9. Epub 2015 Jul 8.