PMID- 26856853
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 233
IP  - 8
DP  - 2016 Apr
TI  - Repeated administration of the 5-HT(1)B/(1)A agonist, RU 24969, facilitates the 
      acquisition of MDMA self-administration: role of 5-HT(1)A and 5-HT(1)B receptor 
      mechanisms.
PG  - 1339-47
LID - 10.1007/s00213-016-4225-x [doi]
AB  - RATIONALE: 3,4 Methylenedioxymethamphetamine (MDMA) preferentially stimulates the 
      release of serotonin (5-HT) that subsequently produces behavioral responses by 
      activation of post-synaptic receptor mechanisms. The 5-HT1A and 5-HT1B receptors 
      are both well localized to regulate dopamine (DA) release, and have been 
      implicated in modulating the reinforcing effects of many drugs of abuse, but a 
      role in acquisition of self-administration has not been determined. OBJECTIVES: 
      This study was designed to determine the effect of pharmacological manipulation 
      of 5-HT1A and 5-HT1B receptor mechanisms on the acquisition of MDMA 
      self-administration. METHODS: The 5-HT1B/1A receptor agonist, RU 24969 (0.0 or 
      3.0 mg/kg, bid), was administered for 3 days in order to down-regulate both 
      5-HT1A and 5-HT1B receptors. Following the pretreatment phase, latency to 
      acquisition of MDMA self-administration was measured. RESULTS: Repeated 
      administration of RU 24969 significantly decreased the latency to acquisition and 
      increased the proportion of animals that acquired MDMA self-administration. 
      Dose-effect curves for the 5-HT1A-mediated hyperactivity produced by the 5-HT1A 
      agonist, 8-OH-DPAT, and the 5-HT1B-mediated adipsic response produced by RU 24969 
      were shifted rightward, suggesting a desensitization of 5-HT1A and 5-HT1B 
      receptor mechanisms. CONCLUSIONS: These data suggest that the initial reinforcing 
      effects of MDMA are modulated by 5-HT1A and/or 5-HT1B receptor mechanisms. The 
      potential impact of these changes on the DAergic response relevant to 
      self-administration and a possible role in conditioned reinforcement pertaining 
      to acquisition of self-administration are discussed.
FAU - Aronsen, Dane
AU  - Aronsen D
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand.
FAU - Bukholt, Natasha
AU  - Bukholt N
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand.
FAU - Schenk, Susan
AU  - Schenk S
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand. Susan.schenk@vuw.ac.nz.
LA  - eng
PT  - Journal Article
DEP - 20160209
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Indoles)
RN  - 0 (Receptor, Serotonin, 5-HT1B)
RN  - 0 (Serotonin 5-HT1 Receptor Agonists)
RN  - 0 (Serotonin Antagonists)
RN  - 112692-38-3 (Receptor, Serotonin, 5-HT1A)
RN  - 2ISE72RACC (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Indoles/*administration & dosage
MH  - Locomotion/drug effects/physiology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Serotonin, 5-HT1A/*physiology
MH  - Receptor, Serotonin, 5-HT1B/*physiology
MH  - Self Administration
MH  - Serotonin 5-HT1 Receptor Agonists/*administration & dosage
MH  - Serotonin Antagonists/pharmacology
OTO - NOTNLM
OT  - 5-HT1A
OT  - 5-HT1B
OT  - Acquisition
OT  - Dopamine
OT  - MDMA
OT  - RU 24969
OT  - Self-administration
OT  - Serotonin
EDAT- 2016/02/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/10 06:00
PHST- 2015/11/04 00:00 [received]
PHST- 2016/01/27 00:00 [accepted]
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1007/s00213-016-4225-x [pii]
AID - 10.1007/s00213-016-4225-x [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2016 Apr;233(8):1339-47. doi: 
      10.1007/s00213-016-4225-x. Epub 2016 Feb 9.