PMID- 26856854
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 233
IP  - 7
DP  - 2016 Apr
TI  - MDMA self-administration fails to alter the behavioral response to 5-HT(1A) and 
      5-HT(1B) agonists.
PG  - 1323-30
LID - 10.1007/s00213-016-4226-9 [doi]
AB  - RATIONALE: Regular use of the street drug, ecstasy, produces a number of 
      cognitive and behavioral deficits. One possible mechanism for these deficits is 
      functional changes in serotonin (5-HT) receptors as a consequence of prolonged 
      3,4 methylenedioxymethamphetamine (MDMA)-produced 5-HT release. Of particular 
      interest are the 5-HT(1A) and 5-HT(1B) receptor subtypes since they have been 
      implicated in several of the behaviors that have been shown to be impacted in 
      ecstasy users and in animals exposed to MDMA. OBJECTIVES: This study aimed to 
      determine the effect of extensive MDMA self-administration on behavioral 
      responses to the 5-HT(1A) agonist, 8-hydroxy-2-(n-dipropylamino)tetralin 
      (8-OH-DPAT), and the 5-HT(1B/1A) agonist, RU 24969. METHODS: Male Sprague-Dawley 
      rats self-administered a total of 350 mg/kg MDMA, or vehicle, over 20-58 daily 
      self-administration sessions. Two days after the last self-administration 
      session, the hyperactive response to 8-OH-DPAT (0.03-1.0 mg/kg) or the adipsic 
      response to RU 24969 (0.3-3.0 mg/kg) were assessed. RESULTS: 8-OH-DPAT dose 
      dependently increased horizontal activity, but this response was not altered by 
      MDMA self-administration. The dose-response curve for RU 24969-produced adipsia 
      was also not altered by MDMA self-administration. CONCLUSIONS: Cognitive and 
      behavioral deficits produced by repeated exposure to MDMA self-administration are 
      not likely due to alterations in 5-HT(1A) or 5-HT(1B) receptor mechanisms.
FAU - Aronsen, Dane
AU  - Aronsen D
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand.
FAU - Schenk, Susan
AU  - Schenk S
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand. Susan.schenk@vuw.ac.nz.
LA  - eng
PT  - Journal Article
DEP - 20160209
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Indoles)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 2ISE72RACC (5-methoxy 3-(1,2,3,6-tetrahydro-4-pyridinyl)1H indole)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Indoles/pharmacology
MH  - Male
MH  - Motor Activity/*drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin Receptor Agonists/pharmacology
OTO - NOTNLM
OT  - 5-HT1A
OT  - 5-HT1B
OT  - 8-OH-DPAT
OT  - MDMA
OT  - RU 24969
OT  - Self-administration
EDAT- 2016/02/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/10 06:00
PHST- 2015/11/26 00:00 [received]
PHST- 2016/01/25 00:00 [accepted]
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1007/s00213-016-4226-9 [pii]
AID - 10.1007/s00213-016-4226-9 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2016 Apr;233(7):1323-30. doi: 
      10.1007/s00213-016-4226-9. Epub 2016 Feb 9.