PMID- 26857018
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20181202
IS  - 1534-6315 (Electronic)
IS  - 1529-7322 (Linking)
VI  - 16
IP  - 3
DP  - 2016 Mar
TI  - Mast Cells and Anaphylaxis.
PG  - 20
LID - 10.1007/s11882-016-0598-5 [doi]
AB  - For half a century, it has been known that the mast cell is the cell responsible 
      for the majority of anaphylactic events. Its mediators, taken as a whole, are 
      capable of producing all of the clinical manifestations of these events. With the 
      discovery of immunoglobulin E (IgE), it was originally felt that the vast 
      majority of anaphylactic episodes were due to antigen coupling with two 
      cell-bound IgE molecules. More recently it has been learned that many episodes 
      are produced by direct activation of mast cells, not involving antigen binding to 
      IgE, and that monomeric IgE under certain conditions can also cause 
      degranulation. Of note--in regard to antigen independent degranulation--are 
      recent reports that the human G-protein-coupled receptor, MRGPRX2, may be the 
      receptor for many drugs and cationic proteins capable of producing direct mast 
      cell degranulation and anaphylactic events.
FAU - Lieberman, Phil
AU  - Lieberman P
AD  - Divisions of Allergy and Immunology, Departments of Medicine and Pediatrics, 
      University of Tennessee, Memphis, TN, USA. aac@allergymemphis.com.
AD  - , 7205 Wolf River Blvd., Suite 200, Germantown, TN, 38138-1777, USA. 
      aac@allergymemphis.com.
FAU - Garvey, Lene Heise
AU  - Garvey LH
AD  - Allergy Clinic UA-816, Department of Dermato-allergology, Copenhagen University 
      Hospital, Gentofte, Kildegardsvej 28, DK-2900, Hellerup, Denmark. 
      lene.heise.garvey@regionh.dk.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Allergy Asthma Rep
JT  - Current allergy and asthma reports
JID - 101096440
RN  - 0 (Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Anaphylaxis/*immunology
MH  - Animals
MH  - Antigens/immunology
MH  - Cell Degranulation
MH  - Humans
MH  - Immunoglobulin E/immunology
MH  - Mast Cells/*immunology
OTO - NOTNLM
OT  - Anaphylaxis
OT  - Basophil
OT  - Immunoglobulin E
OT  - MRGPRX2
OT  - Mast cell
OT  - Mast cell mediators
OT  - Mast cell secretagogues
OT  - Tryptase
EDAT- 2016/02/10 06:00
MHDA- 2016/08/02 06:00
CRDT- 2016/02/10 06:00
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - 10.1007/s11882-016-0598-5 [pii]
AID - 10.1007/s11882-016-0598-5 [doi]
PST - ppublish
SO  - Curr Allergy Asthma Rep. 2016 Mar;16(3):20. doi: 10.1007/s11882-016-0598-5.