PMID- 26857094
OWN - NLM
STAT- MEDLINE
DCOM- 20180314
LR  - 20181211
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 22
IP  - 3
DP  - 2017 May
TI  - Oleoylethanolamide prevents neuroimmune HMGB1/TLR4/NF-kB danger signaling in rat 
      frontal cortex and depressive-like behavior induced by ethanol binge 
      administration.
PG  - 724-741
LID - 10.1111/adb.12365 [doi]
AB  - Alcohol abuse is frequently characterized by a specific pattern of intake in 
      binge drinking episodes, inducing neuroinflammation and brain damage. Here, we 
      characterized the temporal profile of neuroinflammation in rats exposed to 
      intragastric binge ethanol administrations (3 times/day x 4 days) and tested the 
      anti-inflammatory/neuroprotective properties of the satiety factor 
      oleoylethanolamide (OEA). Pre-treatment with OEA (5 mg/kg, i.p.) previous each 
      alcohol gavage blocked the expression of high mobility group box 1 (HMGB1) danger 
      signal and the innate immunity Toll-like receptors 4 (TLR4) in frontal cortex, 
      and inhibited the nuclear factor-kappa B (NF-kB) proinflammatory cascade induced 
      by alcohol binge administration. OEA reduced the levels of interleukin-1beta 
      (IL-1beta), the monocyte chemoattractant protein-1 (MCP-1), and the enzymes 
      cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) in ethanol 
      binged animals. Elevations in plasma tumor necrosis factor alpha (TNF-alpha) and 
      IL-1beta after ethanol were also inhibited by OEA. OEA also prevented 
      ethanol-induced lipid peroxidation, caspase-8 and pro-apoptotic caspase-3 
      activation in frontal cortex. Additionally, OEA blocked the rise in blood 
      corticosterone levels after ethanol with no alteration in blood ethanol levels 
      and may affect ethanol-induced gut permeability for endotoxin. Finally, OEA, 
      administered as a pre-treatment during the ethanol binge, exerted 
      antidepressant-like effects during acute withdrawal. Altogether, results 
      highlight a beneficial profile of OEA as a potent anti-inflammatory, antioxidant, 
      neuroprotective and antidepressant-like compound to treat alcohol abuse.
CI  - (c) 2016 Society for the Study of Addiction.
FAU - Anton, Maria
AU  - Anton M
AD  - Department of Psychobiology, Faculty of Psychology, Complutense University, 
      Spain.
FAU - Alen, Francisco
AU  - Alen F
AD  - Department of Psychobiology, Faculty of Psychology, Complutense University, 
      Spain.
FAU - Gomez de Heras, Raquel
AU  - Gomez de Heras R
AD  - Department of Psychobiology, Faculty of Psychology, Complutense University, 
      Spain.
FAU - Serrano, Antonia
AU  - Serrano A
AD  - Instituto de Investigacion Biomedica (IBIMA), Malaga, and Red de Trastornos 
      Adictivos (RTA), Spain.
FAU - Pavon, Francisco Javier
AU  - Pavon FJ
AD  - Instituto de Investigacion Biomedica (IBIMA), Malaga, and Red de Trastornos 
      Adictivos (RTA), Spain.
FAU - Leza, Juan Carlos
AU  - Leza JC
AD  - Department of Pharmacology, Faculty of Medicine, UCM, and Centro de Investigacion 
      Biomedica en Red de Salud Mental (CIBERSAM) & Imas12, Spain.
FAU - Garcia-Bueno, Borja
AU  - Garcia-Bueno B
AD  - Department of Pharmacology, Faculty of Medicine, UCM, and Centro de Investigacion 
      Biomedica en Red de Salud Mental (CIBERSAM) & Imas12, Spain.
FAU - Rodriguez de Fonseca, Fernando
AU  - Rodriguez de Fonseca F
AD  - Department of Psychobiology, Faculty of Psychology, Complutense University, 
      Spain.
AD  - Instituto de Investigacion Biomedica (IBIMA), Malaga, and Red de Trastornos 
      Adictivos (RTA), Spain.
FAU - Orio, Laura
AU  - Orio L
AD  - Department of Psychobiology, Faculty of Psychology, Complutense University, 
      Spain.
LA  - eng
PT  - Journal Article
DEP - 20160209
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Endocannabinoids)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Hbp1 protein, rat)
RN  - 0 (NF-kappa B)
RN  - 0 (Oleic Acids)
RN  - 0 (Toll-Like Receptor 4)
RN  - 1HI5J9N8E6 (oleoylethanolamide)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Binge Drinking/*complications
MH  - Depressive Disorder/*chemically induced/prevention & control
MH  - Disease Models, Animal
MH  - Endocannabinoids/*pharmacology
MH  - Ethanol/pharmacology
MH  - Frontal Lobe/*drug effects/metabolism
MH  - HMGB1 Protein/*drug effects/genetics/metabolism
MH  - Male
MH  - Mice
MH  - NF-kappa B/*drug effects/metabolism
MH  - Neuroimmunomodulation/drug effects
MH  - Oleic Acids/*pharmacology
MH  - Rats, Wistar
MH  - Signal Transduction/drug effects
MH  - Toll-Like Receptor 4/*drug effects/metabolism
OTO - NOTNLM
OT  - Alcohol binge
OT  - HMGB1
OT  - TLR4
OT  - neuroinflammation
OT  - neuroprotection
OT  - oleoylethanolamide
EDAT- 2016/02/10 06:00
MHDA- 2018/03/15 06:00
CRDT- 2016/02/10 06:00
PHST- 2015/06/03 00:00 [received]
PHST- 2015/10/31 00:00 [revised]
PHST- 2015/12/11 00:00 [accepted]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2018/03/15 06:00 [medline]
PHST- 2016/02/10 06:00 [entrez]
AID - 10.1111/adb.12365 [doi]
PST - ppublish
SO  - Addict Biol. 2017 May;22(3):724-741. doi: 10.1111/adb.12365. Epub 2016 Feb 9.