PMID- 26857862
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20211203
IS  - 1473-2300 (Electronic)
IS  - 0300-0605 (Print)
IS  - 0300-0605 (Linking)
VI  - 44
IP  - 2
DP  - 2016 Apr
TI  - Adipokine zinc-alpha-2-glycoprotein as a novel urinary biomarker presents earlier 
      than microalbuminuria in diabetic nephropathy.
PG  - 278-86
LID - 10.1177/0300060515601699 [doi]
AB  - OBJECTIVE: To investigate the role of zinc-alpha-2-glycoprotein (ZAG) in the 
      early stage of diabetic nephropathy, in patients with type 2 diabetes mellitus 
      (T2DM). METHODS: This cross-sectional observational study recruited patients with 
      longstanding T2DM and healthy control subjects. Patients with T2DM were further 
      stratified based on their urine albumin-creatinine ratio (UACR) and estimated 
      glomerular filtration rate (eGFR). Serum and urine concentrations of ZAG were 
      determined using an enzyme-linked immunosorbent assay. RESULTS: Eighty patients 
      with T2DM and 20 healthy control subjects were enrolled in the study. Mean +/- SD 
      concentrations of ZAG in serum and urine were both significantly higher in 
      patients with T2DM (serum: 38.29 +/- 22.72 mg/l; urine: 53.64 +/- 29.48 mg/g) 
      compared with concentrations in healthy control subjects (serum: 
      21.61 +/- 8.83 mg/l; urine: 28.17 +/- 10.64 mg/g). Serum ZAG concentration was 
      positively correlated with serum creatinine and eGFR. Urine ZAG concentration was 
      positively correlated with UACR. Urine concentration of ZAG in the higher eGFR 
      group was higher than that in the normal eGFR group (41.26 +/- 13.67 versus 
      32.05 +/- 8.55 mg/g, respectively). CONCLUSION: These preliminary findings suggest 
      that ZAG might be a potentially useful biomarker for early diagnosis of diabetic 
      nephropathy in patients with T2DM.
CI  - (c) The Author(s) 2016.
FAU - Wang, Yuan
AU  - Wang Y
AD  - Department of Nephrology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning Province, China.
FAU - Li, Yan-Mei
AU  - Li YM
AD  - Department of Nephrology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning Province, China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - Department of Nephrology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning Province, China.
FAU - Zhao, Jiu-Yang
AU  - Zhao JY
AD  - Department of Nephrology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning Province, China.
FAU - Liu, Chun-Yan
AU  - Liu CY
AD  - Department of Nephrology, The Second Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning Province, China 15541117239@163.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20160208
PL  - England
TA  - J Int Med Res
JT  - The Journal of international medical research
JID - 0346411
RN  - 0 (Biomarkers)
RN  - 0 (Seminal Plasma Proteins)
RN  - 0 (Serum Albumin)
RN  - 0 (Zn-Alpha-2-Glycoprotein)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Albuminuria/blood/*diagnosis/physiopathology/urine
MH  - Biomarkers/urine
MH  - Case-Control Studies
MH  - Creatinine/blood
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis/physiopathology/urine
MH  - Diabetic Nephropathies/blood/*diagnosis/physiopathology/urine
MH  - Early Diagnosis
MH  - Female
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Seminal Plasma Proteins/*urine
MH  - Serum Albumin/metabolism
MH  - Zn-Alpha-2-Glycoprotein
PMC - PMC5580061
OTO - NOTNLM
OT  - Zinc-alpha-2-glycoprotein
OT  - albuminuria
OT  - biomarker
OT  - diabetic nephropathy
EDAT- 2016/02/10 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/04/01
CRDT- 2016/02/10 06:00
PHST- 2015/01/22 00:00 [received]
PHST- 2015/07/26 00:00 [accepted]
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 0300060515601699 [pii]
AID - 10.1177_0300060515601699 [pii]
AID - 10.1177/0300060515601699 [doi]
PST - ppublish
SO  - J Int Med Res. 2016 Apr;44(2):278-86. doi: 10.1177/0300060515601699. Epub 2016 
      Feb 8.