PMID- 26857932
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20211214
IS  - 0975-5764 (Electronic)
IS  - 1596-3519 (Print)
IS  - 0975-5764 (Linking)
VI  - 15
IP  - 1
DP  - 2016 Jan-Mar
TI  - Relationship between serum leptin and insulin resistance among obese Nigerian 
      women.
PG  - 14-9
AB  - BACKGROUND: Leptin is a hormone produced directly from adipocytes and has been 
      associated with type 2 diabetes mellitus (T2DM) which is characterized by insulin 
      resistance (IR). Due to the increasing prevalence of obesity in sub-Saharan 
      Africa, serum leptin can be explored as a predictive risk factor for T2DM. 
      Therefore, the aim of this study was to determine the relationship between serum 
      leptin and IR among obese women. METHODS: This was a cross-sectional study of 
      obese, adult Nigerian females. Participants with body mass index (BMI) >/=30 kg/m2 
      and nondiabetic were recruited as subjects. Fasting serum leptin, insulin, and 
      plasma glucose were determined. IR was calculated using the formula: Homeostatic 
      model assessment-IR (HOMA-IR) = (glucose x insulin)/22.5. Statistical analyses 
      were performed using SPSS and P < 0.05 was considered to be significant. RESULTS: 
      Eighty obese females with mean +/- standard deviation BMI 39.1 +/- 7.2 kg/m2 and 
      serum leptin level 48.4 +/- 24.4 ng/ml participated in study. Prevalence of 
      hyperleptinemia was 92.5% (confidence interval: 87.3-97.7%). The relationship 
      between leptin and HOMA-IR among the subjects was: BMI 30-34.9 kg/m2: n = 27, r = 
      0.18, P = 0.42; BMI 35-39.9 kg/m2: n = 24, r = 0.36, P = 0.11; BMI >/= 40 kg/m2: n 
      = 29, r = 0.52, P = 0.004*; and after controlling for BMI (n = 29, r = 0.46, P = 
      0.014*). Multiple linear regression showed that leptin did not predict for IR (P 
      = 0.837). CONCLUSION: Serum leptin levels were positively correlated with IR, 
      which was significant among the Class III (morbid) obesity class. However, leptin 
      was not a predictive factor for IR in obese Nigerian women.
FAU - Osegbe, Ifeyinwa
AU  - Osegbe I
AD  - Department of Chemical Pathology, University of Nigeria Teaching Hospital, Enugu, 
      Nigeria.
FAU - Okpara, Henry
AU  - Okpara H
FAU - Azinge, Elaine
AU  - Azinge E
LA  - eng
PT  - Journal Article
PL  - India
TA  - Ann Afr Med
JT  - Annals of African medicine
JID - 101231417
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (LEPR protein, human)
RN  - 0 (Leptin)
RN  - 0 (Receptors, Leptin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis
MH  - Body Mass Index
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - *Insulin Resistance
MH  - Leptin/*blood
MH  - Middle Aged
MH  - Obesity/*blood
MH  - Receptors, Leptin
MH  - Risk Factors
PMC - PMC5452686
COIS- There are no conflicts of interest.
EDAT- 2016/02/10 06:00
MHDA- 2016/07/07 06:00
PMCR- 2016/01/01
CRDT- 2016/02/10 06:00
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - AnnAfrMed_2016_15_1_14_158524 [pii]
AID - AAM-15-14 [pii]
AID - 10.4103/1596-3519.158524 [doi]
PST - ppublish
SO  - Ann Afr Med. 2016 Jan-Mar;15(1):14-9. doi: 10.4103/1596-3519.158524.