PMID- 26858928
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160209
LR  - 20200930
IS  - 2186-6953 (Print)
IS  - 2186-3342 (Electronic)
IS  - 2186-3342 (Linking)
VI  - 35
IP  - 1
DP  - 2016
TI  - Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 
      0132 on atopic dermatitis: results of daily intake by adult patients in two open 
      trials.
PG  - 29-39
LID - 10.12938/bmfh.2015-010 [doi]
AB  - This study aimed to examine whether daily intake of citrus juice containing 
      heat-killed Lactobacillus plantarum YIT 0132 (LP0132-fermented juice) alleviates 
      symptoms of atopic dermatitis. This was a natural extension of our previous study 
      in which LP0132 was shown to enhance IL-10 production in vitro and 
      LP0132-fermented juice was found to alleviate symptoms and enhance quality of 
      life (QOL) in patients with Japanese cedar pollinosis. In two open trials, Trial 
      1 and Trial 2, 32 and 18 adult patients with mild to moderate atopic dermatitis 
      consumed LP0132-fermented juice for 8 weeks. Skin conditions and QOL were 
      subjectively evaluated using Skindex-16 before intake of the juice 
      (Pre-treatment), 8 weeks after starting intake (Treatment) and 8 weeks after 
      termination of intake (Post-treatment). Blood parameters were also analyzed. 
      Comparison of the Treatment and Post-treatment time points with the Pre-treatment 
      time point revealed significant reductions in the Skindex-16 overall score and 
      the 3 domain subscores (symptoms, emotions, and functioning domains) in both 
      trials. Moreover, blood levels of eosinophil cationic protein (ECP), total 
      immunoglobulin E (IgE) and specific IgEs for Japanese cedar and cypress pollen 
      were significantly attenuated in Trial 2. The findings suggest that daily intake 
      of citrus fermented juice containing heat-killed LP0132 has beneficial effects on 
      symptoms and QOL in patients with mild to moderate atopic dermatitis due to an 
      immunomodulatory effect via attenuation of IgE and ECP.
FAU - Harima-Mizusawa, Naomi
AU  - Harima-Mizusawa N
AD  - Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Kamachi, Keiko
AU  - Kamachi K
AD  - Kagawa Nutrition University, 3-24-3 Komagome, Toshima-ku, Tokyo 170-8481, Japan.
FAU - Kano, Mitsuyoshi
AU  - Kano M
AD  - Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Nozaki, Daisuke
AU  - Nozaki D
AD  - Yakult Honsha Co., Ltd., 1-19 Higashi Shimbashi 1-chome, Minato-ku, Tokyo 
      105-8660, Japan.
FAU - Uetake, Tatsuo
AU  - Uetake T
AD  - RIKEN Innovation Center, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 
      351-0198, Japan.
FAU - Yokomizo, Yuji
AU  - Yokomizo Y
AD  - RIKEN Innovation Center, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 
      351-0198, Japan.
FAU - Nagino, Takayuki
AU  - Nagino T
AD  - Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Tanaka, Akira
AU  - Tanaka A
AD  - Kagawa Nutrition University, 3-24-3 Komagome, Toshima-ku, Tokyo 170-8481, Japan.
FAU - Miyazaki, Kouji
AU  - Miyazaki K
AD  - Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan.
FAU - Nakamura, Shinichiro
AU  - Nakamura S
AD  - RIKEN Innovation Center, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 
      351-0198, Japan.
LA  - eng
PT  - Journal Article
DEP - 20151027
PL  - Japan
TA  - Biosci Microbiota Food Health
JT  - Bioscience of microbiota, food and health
JID - 101578264
PMC - PMC4735031
OTO - NOTNLM
OT  - Lactobacillus plantarum
OT  - Skindex-16
OT  - atopic dermatitis
OT  - citrus juice
OT  - eosinophil cationic protein
OT  - immunoglobulin E
OT  - quality of life
EDAT- 2016/02/10 06:00
MHDA- 2016/02/10 06:01
PMCR- 2016/01/01
CRDT- 2016/02/10 06:00
PHST- 2015/06/04 00:00 [received]
PHST- 2015/09/28 00:00 [accepted]
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/02/10 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 2015-010 [pii]
AID - 10.12938/bmfh.2015-010 [doi]
PST - ppublish
SO  - Biosci Microbiota Food Health. 2016;35(1):29-39. doi: 10.12938/bmfh.2015-010. 
      Epub 2015 Oct 27.