PMID- 26859236
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220321
IS  - 1879-1379 (Electronic)
IS  - 0022-3956 (Linking)
VI  - 76
DP  - 2016 May
TI  - Electroconvulsive therapy (ECT) and aerobic exercise training (AET) increased 
      plasma BDNF and ameliorated depressive symptoms in patients suffering from major 
      depressive disorder.
PG  - 1-8
LID - S0022-3956(16)30011-5 [pii]
LID - 10.1016/j.jpsychires.2016.01.012 [doi]
AB  - BACKGROUND: To treat patients suffering from major depressive disorder (MDD), 
      research has focused on electroconvulsive therapy (ECT) and aerobic exercise 
      training (AET). Brain derived neurotrophic factor (BDNF) seems to be key in MDD. 
      The aims of the present study were therefore two-fold, to investigate in a 
      three-arm interventional study the differential effects of ECT, ECT plus AET, and 
      AET alone in patients suffering from TR-MDD on 1. depressive symptoms and 2. 
      plasma BDNF (pBDNF). METHODS: 60 patients with MDD (mean age: 31 years; 31.6% 
      female patients) were randomly assigned either to the ECT, ECT + AET, or AET 
      condition. The AET condition consisted of treadmill exercise for 45 min, three 
      times a week. Both depression severity and pBDNF levels were assessed at baseline 
      and 4 weeks later. All patients were further treated with an SSRI standard 
      medication. RESULTS: pBDNF levels increased over time in all three study 
      conditions, though, highest increase was observed in the ECT + EAT condition, and 
      lowest increase was observed in the AET condition. Depressive symptoms decreased 
      in all three conditions over time, though, strongest decrease was observed in the 
      ECT + AET condition. The combination of ECT + AET led to significantly greater 
      remission rates than in either the ECT or AET alone conditions. BDNF levels were 
      not associated with symptoms of depression. CONCLUSIONS: The pattern of results 
      suggests that ECT, AET and particularly their combination are promising 
      directions for the treatment of patients suffering from MDD, and that it remains 
      unclear to what extent pBDNF is key and a reliable biomarker for MDD.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - Salehi, Iraj
AU  - Salehi I
AD  - Research Center For Behavioral Disorders and Substances Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Hosseini, Seyed Mohammad
AU  - Hosseini SM
AD  - Research Center For Behavioral Disorders and Substances Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Haghighi, Mohammad
AU  - Haghighi M
AD  - Research Center For Behavioral Disorders and Substances Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Jahangard, Leila
AU  - Jahangard L
AD  - Research Center For Behavioral Disorders and Substances Abuse, Hamadan University 
      of Medical Sciences, Hamadan, Iran.
FAU - Bajoghli, Hafez
AU  - Bajoghli H
AD  - Iranian National Center for Addiction Studies (INCAS), Tehran University of 
      Medical Sciences, Tehran, Iran.
FAU - Gerber, Markus
AU  - Gerber M
AD  - Department of Sport, Exercise and Health, Sport Science Section, University of 
      Basel, Basel, Switzerland.
FAU - Puhse, Uwe
AU  - Puhse U
AD  - Department of Sport, Exercise and Health, Sport Science Section, University of 
      Basel, Basel, Switzerland.
FAU - Holsboer-Trachsler, Edith
AU  - Holsboer-Trachsler E
AD  - Psychiatric Clinics of the University of Basel, Center for Affective, Stress and 
      Sleep Disorders (ZASS), Basel, Switzerland.
FAU - Brand, Serge
AU  - Brand S
AD  - Department of Sport, Exercise and Health, Sport Science Section, University of 
      Basel, Basel, Switzerland; Psychiatric Clinics of the University of Basel, Center 
      for Affective, Stress and Sleep Disorders (ZASS), Basel, Switzerland. Electronic 
      address: serge.brand@upkbs.ch.
LA  - eng
PT  - Journal Article
DEP - 20160125
PL  - England
TA  - J Psychiatr Res
JT  - Journal of psychiatric research
JID - 0376331
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/*therapy
MH  - Electroconvulsive Therapy/*methods
MH  - Exercise Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychiatric Status Rating Scales
MH  - Self Report
MH  - Statistics as Topic
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - Aerobic exercise training
OT  - Electroconvulsive therapy
OT  - Major depressive disorder
OT  - Plasma BDNF
EDAT- 2016/02/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/10 06:00
PHST- 2015/10/29 00:00 [received]
PHST- 2016/01/14 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0022-3956(16)30011-5 [pii]
AID - 10.1016/j.jpsychires.2016.01.012 [doi]
PST - ppublish
SO  - J Psychiatr Res. 2016 May;76:1-8. doi: 10.1016/j.jpsychires.2016.01.012. Epub 
      2016 Jan 25.