PMID- 26859449
OWN - NLM
STAT- MEDLINE
DCOM- 20160623
LR  - 20181202
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Linking)
VI  - 29
IP  - 2
DP  - 2016 Feb 8
TI  - miR-126 Drives Quiescence and Self-Renewal in Leukemic Stem Cells.
PG  - 133-5
LID - S1535-6108(16)30001-0 [pii]
LID - 10.1016/j.ccell.2016.01.007 [doi]
AB  - Leukemic stem cells (LSCs) are resistant to conventional chemotherapy and promote 
      acute myeloid leukemia (AML) progression and recurrence. In this issue of Cancer 
      Cell, Lechman and colleagues (2016) identify the microRNA miR-126 as a regulator 
      of PI3K-AKT-mTOR and CDK3 signaling driving LSC self-renewal and chemotherapy 
      resistance.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Raffel, Simon
AU  - Raffel S
AD  - Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM 
      gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches 
      Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany.
FAU - Trumpp, Andreas
AU  - Trumpp A
AD  - Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM 
      gGmbH), 69120 Heidelberg, Germany; Division of Stem Cells and Cancer, Deutsches 
      Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany. Electronic address: 
      a.trumpp@dkfz.de.
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (MicroRNAs)
SB  - IM
CON - Cancer Cell. 2016 Feb 8;29(2):214-28. PMID: 26832662
MH  - Animals
MH  - Hematopoietic Stem Cells/*pathology
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*pathology
MH  - MicroRNAs/*physiology
EDAT- 2016/02/10 06:00
MHDA- 2016/06/24 06:00
CRDT- 2016/02/10 06:00
PHST- 2016/02/10 06:00 [entrez]
PHST- 2016/02/10 06:00 [pubmed]
PHST- 2016/06/24 06:00 [medline]
AID - S1535-6108(16)30001-0 [pii]
AID - 10.1016/j.ccell.2016.01.007 [doi]
PST - ppublish
SO  - Cancer Cell. 2016 Feb 8;29(2):133-5. doi: 10.1016/j.ccell.2016.01.007.