PMID- 26859774 OWN - NLM STAT- MEDLINE DCOM- 20160719 LR - 20190222 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 11 IP - 2 DP - 2016 TI - Psychometric Properties of Prodromal Questionnaire-Brief Version among Chinese Help-Seeking Individuals. PG - e0148935 LID - 10.1371/journal.pone.0148935 [doi] LID - e0148935 AB - Prodromal Questionnaire (PQ) and Structured Interview for Prodromal Syndromes (SIPS) have been used as a two-stage process for identifying subjects at clinical high risk (CHR) of psychosis. The Prodromal Questionnaire-Brief version (PQ-B) contains 21 items derived from the PQ. The present study aimed to examine the psychometric properties of PQ-B in a Chinese help-seeking outpatient sample and to explore which items can better predict CHR diagnosis by SIPS and future transition to psychosis. In our preliminary epidemiological study, 1461 patients from a pool of 2101 individuals (15-45 years of age) completed the two-stage process. In the present study, 239 (20%) people were randomly selected among the sample who met the initial PQ-B screening criteria but had no positive diagnosis on SIPS, as well as 72 individuals with negative results on both PQ-B and SIPS, 89 prodromal and 105 psychotic subjects, yielding a total of 505 participants. The internal consistency coefficient for the PQ-B was good, with a Cronbach's alpha of 0.897. The concordant validity of PQ-B with SIPS dichotomized diagnosis of prodrome/psychosis versus no psychosis was 0.54. To ensure 80% or a higher sensitivity and a certain specificity, 7 and 24 were respectively set as the cutoff points for the PQ-B total score and distress score for Chinese help-seeking outpatients. A logistic regression model based on six PQ-B items could allow predicting the psychotic diagnosis on SIPS, with an accuracy of 65.8%. Prodromal individuals who scored higher on the 12th item of PQ-B (Do you worry at times that something may be wrong with your mind?) were less likely to convert to psychosis. PQ-B is a useful instrument for screening CHR subjects, but the cutoff score may be higher than that recommended by the author scores for help-seeking individuals in outpatient clinics. Some specific PQ-B items may have significant predictive power on dichotomized SIPS diagnoses and deserve special attention from researchers in future studies. FAU - Xu, LiHua AU - Xu L AD - Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Zhang, TianHong AU - Zhang T AD - Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Zheng, LiNa AU - Zheng L AD - Department of Psychiatry, Liaocheng People's Hospital, Liaocheng, Shandong, China. FAU - Li, HuiJun AU - Li H AD - Department of Psychology, Florida Agricultural & Mechanical University, Tallahassee, Florida, United States of America. AD - Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America. FAU - Tang, YingYing AU - Tang Y AD - Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Luo, XingGuang AU - Luo X AD - Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America. AD - VA Connecticut Healthcare System, West Haven Campus, West Haven, Connecticut, United States of America. AD - Biological Psychiatry Research Center, Beijing Huilongguan Hospital, Beijing, China. FAU - Sheng, JianHua AU - Sheng J AD - Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Wang, JiJun AU - Wang J AD - Shanghai Key Laboratory of Psychotic Disorders, Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160209 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Adult MH - China MH - Female MH - *Help-Seeking Behavior MH - Humans MH - Male MH - Middle Aged MH - Patient Acceptance of Health Care/*psychology/statistics & numerical data MH - *Prodromal Symptoms MH - Psychometrics MH - Psychotic Disorders/diagnosis/*psychology MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Young Adult PMC - PMC4747512 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2016/02/10 06:00 MHDA- 2016/07/20 06:00 PMCR- 2016/02/09 CRDT- 2016/02/10 06:00 PHST- 2015/07/24 00:00 [received] PHST- 2016/01/24 00:00 [accepted] PHST- 2016/02/10 06:00 [entrez] PHST- 2016/02/10 06:00 [pubmed] PHST- 2016/07/20 06:00 [medline] PHST- 2016/02/09 00:00 [pmc-release] AID - PONE-D-15-31973 [pii] AID - 10.1371/journal.pone.0148935 [doi] PST - epublish SO - PLoS One. 2016 Feb 9;11(2):e0148935. doi: 10.1371/journal.pone.0148935. eCollection 2016.