PMID- 26860674
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20181202
IS  - 1872-7727 (Electronic)
IS  - 0720-048X (Linking)
VI  - 85
IP  - 3
DP  - 2016 Mar
TI  - Abnormal spontaneous brain activity in type 2 diabetes with and without 
      microangiopathy revealed by regional homogeneity.
PG  - 607-15
LID - S0720-048X(15)30208-4 [pii]
LID - 10.1016/j.ejrad.2015.12.024 [doi]
AB  - PURPOSE: To investigate whether global spontaneous brain activity changes in type 
      2 diabetes mellitus (T2DM) patients and these changes vary according to the 
      degree of microangiopathy. MATERIALS AND METHODS: T2DM patients with (M(+), n=26) 
      and without (M(-), n=22) microangiopathy as well as 28 healthy nondiabetic 
      subjects were enrolled in this study. All the subjects completed a resting-state 
      functional magnetic resonance imaging (rs-fMRI) examination and 
      neuropsychological assessment. Regional homogeneity (ReHo) values, representing 
      spontaneous brain activity, were calculated and compared between M(+) and M(-) 
      T2DM patients and nondiabetic controls. RESULTS: In both M(+) and M(-) T2DM 
      patients, ReHo values were decreased in the occipital lobe, temporal lobe, 
      postcentral gyrus, and cerebellum, while increased in the bilateral precuneus, 
      superior/middle frontal gyrus, and insula. Compared with the M(-) group, M(+) 
      patients showed decreased ReHo values in the left cuneus and superior occipital 
      gyrus. The ReHo values in the lingual gyrus/calcarine cortex and MTG were related 
      to clinical parameters in T2DM patients. CONCLUSION: The abnormalities of 
      spontaneous brain activity revealed by ReHo values in both M(+)and M(-) T2DM 
      patients may provide insights into the neurological pathophysiology underlying 
      diabetes-related cognitive impairments. M(+) patients showed more decreased brain 
      activity related to severely impaired function of visual processing and visual 
      memory.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Peng, Juan
AU  - Peng J
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: pengjuan1209@126.com.
FAU - Qu, Hang
AU  - Qu H
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: quhang126@126.com.
FAU - Peng, Jing
AU  - Peng J
AD  - Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan 430030 China. Electronic 
      address: ppjj6@126.com.
FAU - Luo, Tian-You
AU  - Luo TY
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: ltycqfs@126.com.
FAU - Lv, Fa-Jin
AU  - Lv FJ
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: fajinlv@hotmail.com.
FAU - Chen, Li
AU  - Chen L
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: 30733281@qq.com.
FAU - Wang, Zhuo-Nan
AU  - Wang ZN
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: wangzhuonan424@hotmail.com.
FAU - Ouyang, Yu
AU  - Ouyang Y
AD  - Department of Radiology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: 1957ouyangyu@sina.com.
FAU - Cheng, Qing-Feng
AU  - Cheng QF
AD  - Department of Endocrinology, the First Affiliated Hospital, Chongqing Medical 
      University, No. 1 Youyi Road, Yuzhong District, Chongqing 400016, China. 
      Electronic address: cqf19760516@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160102
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
SB  - IM
MH  - Brain/*physiopathology
MH  - Brain Mapping/*methods
MH  - Diabetes Mellitus, Type 2/*complications/*physiopathology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
OTO - NOTNLM
OT  - Cognitive impairment
OT  - Microangiopathy
OT  - Regional homogeneity
OT  - Resting-state fMRI
OT  - Type 2 diabetes
EDAT- 2016/02/11 06:00
MHDA- 2016/10/07 06:00
CRDT- 2016/02/11 06:00
PHST- 2015/08/18 00:00 [received]
PHST- 2015/12/12 00:00 [revised]
PHST- 2015/12/27 00:00 [accepted]
PHST- 2016/02/11 06:00 [entrez]
PHST- 2016/02/11 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
AID - S0720-048X(15)30208-4 [pii]
AID - 10.1016/j.ejrad.2015.12.024 [doi]
PST - ppublish
SO  - Eur J Radiol. 2016 Mar;85(3):607-15. doi: 10.1016/j.ejrad.2015.12.024. Epub 2016 
      Jan 2.