PMID- 26860809 OWN - NLM STAT- MEDLINE DCOM- 20160930 LR - 20220410 IS - 1873-6963 (Electronic) IS - 0965-2299 (Linking) VI - 24 DP - 2016 Feb TI - Impact of prebiotic supplementation on T-cell subsets and their related cytokines, anthropometric features and blood pressure in patients with type 2 diabetes mellitus: A randomized placebo-controlled Trial. PG - 96-102 LID - S0965-2299(15)30031-5 [pii] LID - 10.1016/j.ctim.2015.12.010 [doi] AB - BACKGROUNDS AND AIMS: Type 2 diabetic mellitus (T2DM) asone of the main causes of morbidity and mortality is associated with immune system disturbances and metabolic abnormalities. In the current study we aimed to evaluate the effects of oligofructose-enriched inulin on T-cell subsets and their related cytokines, anthropometric and metabolic parameters in patients with T2DM. METHODS: Forty-six diabetic females patients were randomly allocated into intervention (n=27) and control (n=22) groups. Subjects in the intervention group received a daily dose of 10g of oligofructose-enriched inulin and subjects in control group received a placebo for two months. Anthropometric variables, metabolic parameters including fasting serum glucose (FSG), hemoglobin A1c (HbA1c), lipid profile and blood pressure were measured at the beginning and after two months. Immune markers also included serum interleukin (IL)-4, IL-12 and interferon (IFN)-gamma concentrations were assessed and CD3(+), CD4(+), CD8(+) and CD11b(+)T-cell counts were determined by flow cytometry at baseline and end of the trial. RESULTS: After two months intervention, significant improvements in anthropometric variables, blood pressure and serum lipids occurred in prebiotic-treated group (P<0.001). Serum IL-4, IL-12 and IFN-gamma concentrationsalso significantly decreased in intervention group (P<0.001). No significant changes in CD3(+), CD4(+), CD8(+) and CD11b(+) T-cell counts were observed in treatment groups after intervention. CONCLUSION: The present study showed several beneficial effects of oligofructose-enriched inulin on the improvement of the glycemic status, lipid profile, and immune markers in patients with T2DM. Further studies are needed to confirming our findings and to better clarify the underlying mechanisms. CI - Copyright (c) 2015 Elsevier Ltd. All rights reserved. FAU - Dehghan, Parvin AU - Dehghan P AD - Assistant Professor, Department of Food Science and Technology, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: dehghan.nut@gmail.com. FAU - Farhangi, Mahdieh Abbasalizad AU - Farhangi MA AD - Assistant Professor, Department of Nutrition in Community, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: abbasalizad_m@yahoo.com. FAU - Tavakoli, Farnaz AU - Tavakoli F AD - Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: farnaz.tavakkoli62@gmail.com. FAU - Aliasgarzadeh, Akbar AU - Aliasgarzadeh A AD - Bone Research Center, Endocrine Section, Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz. Electronic address: endocrinology_tabriz@yahoo.com. FAU - Akbari, Aliakbar Movasaghpour AU - Akbari AM AD - Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: movassaghpour@gmail.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20151228 PL - Scotland TA - Complement Ther Med JT - Complementary therapies in medicine JID - 9308777 RN - 0 (Cytokines) RN - 0 (Prebiotics) SB - IM MH - Adult MH - Aged MH - Blood Pressure/*physiology MH - Body Weight MH - Cytokines/*blood MH - Diabetes Mellitus, Type 2/*diet therapy/*epidemiology/physiopathology MH - Female MH - Humans MH - Iran MH - Middle Aged MH - *Prebiotics MH - T-Lymphocyte Subsets/*physiology OTO - NOTNLM OT - Blood pressure OT - Cytokines OT - Prebiotic OT - T-cell subsets OT - Type 2 diabetic mellitus EDAT- 2016/02/11 06:00 MHDA- 2016/10/01 06:00 CRDT- 2016/02/11 06:00 PHST- 2015/04/07 00:00 [received] PHST- 2015/12/12 00:00 [revised] PHST- 2015/12/21 00:00 [accepted] PHST- 2016/02/11 06:00 [entrez] PHST- 2016/02/11 06:00 [pubmed] PHST- 2016/10/01 06:00 [medline] AID - S0965-2299(15)30031-5 [pii] AID - 10.1016/j.ctim.2015.12.010 [doi] PST - ppublish SO - Complement Ther Med. 2016 Feb;24:96-102. doi: 10.1016/j.ctim.2015.12.010. Epub 2015 Dec 28.