PMID- 26861177
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20231213
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 157
DP  - 2016 Apr 1
TI  - Antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal 
      hypothyroidism.
PG  - 158-64
LID - S0031-9384(16)30049-X [pii]
LID - 10.1016/j.physbeh.2016.02.005 [doi]
AB  - Thyroidectomy is a surgical procedure indicated in cases of several maligned or 
      benign thyroid diseases, thus, the aim of our study was to verify how the 
      hypothyroidism induced by thyroidectomy influences behavioral parameters and its 
      relation to thyroid hormones metabolism and neurogenesis at hippocampus. For this 
      purpose, Adult male Wistar rats underwent to thyroidectomy to induce 
      hypothyroidism. Behavioral tests, the thyroid profile and hippocampal gene 
      expression were evaluated in control and in thyroidectomized animals. It was 
      observed that thyroidectomized group had a significant increasing in serum 
      thyroid-stimulating hormone (TSH) and a decreasing in thyroxine (T4) levels as 
      well as in triiodothyronine (T3) serum level. It was also observed reduction of 
      the monocarboxylate transporter 8 (Mct8), thyroid hormone receptor alfa (Tralpha1), 
      deiodinase type 2 (Dio2), ectonucleotide pyrophosphatase/phosphodiesterase 2 
      (Enpp2) and brain-derived neurotrophic factor (Bdnf) mRNA expression in 
      hippocampus of thyroidectomized animals. In the forced swimming test, it was 
      verified that thyroidectomy promotes a decrease in time of immobility and 
      climbing when compared with the control group. In summary, we demonstrated that 
      antidepressant behavior in thyroidectomized Wistar rats is induced by hippocampal 
      hypothyroidism. This effect could be associated to an impaired neuronal activity 
      in acute stress response as it is observed in forced swimming paradigm.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - da Conceicao, Rodrigo Rodrigues
AU  - da Conceicao RR
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Laureano-Melo, Roberto
AU  - Laureano-Melo R
AD  - Departamento de Tecnologia de Alimentos, Instituto de Tecnologia, Universidade 
      Federal Rural do Rio de Janeiro, Seropedica, RJ, Brazil.
FAU - Oliveira, Kelen Carneiro
AU  - Oliveira KC
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - de Carvalho Melo, Maria Clara
AU  - de Carvalho Melo MC
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Kasamatsu, Tereza Sayoko
AU  - Kasamatsu TS
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - de Barros Maciel, Rui Monteiro
AU  - de Barros Maciel RM
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - de Souza, Janaina Sena
AU  - de Souza JS
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Giannocco, Gisele
AU  - Giannocco G
AD  - Laboratorio de Endocrinologia Molecular e Translacional, Departamento de 
      Medicina, Universidade Federal de Sao Paulo, Sao Paulo, SP, Brazil; Departamento 
      de Ciencias Biologicas, Universidade Federal de Sao Paulo, Diadema, SP, Brazil. 
      Electronic address: ggiannocco@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160206
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Monocarboxylic Acid Transporters)
RN  - 0 (RNA, Messenger)
RN  - 0 (monocarboxylate transporter 8, rat)
RN  - 06LU7C9H1V (Triiodothyronine)
RN  - 9002-71-5 (Thyrotropin)
RN  - EC 1.11.1.8 (Iodide Peroxidase)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.39 (alkylglycerophosphoethanolamine phosphodiesterase)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Disease Models, Animal
MH  - Exploratory Behavior
MH  - Gene Expression Regulation/*physiology
MH  - Hippocampus/*metabolism
MH  - Hypothyroidism/*etiology/*pathology
MH  - Iodide Peroxidase/genetics/metabolism
MH  - Male
MH  - Monocarboxylic Acid Transporters/genetics/metabolism
MH  - Phosphoric Diester Hydrolases/genetics/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Swimming/psychology
MH  - Thyroidectomy/*adverse effects
MH  - Thyrotropin/blood
MH  - Triiodothyronine/metabolism
MH  - Iodothyronine Deiodinase Type II
OTO - NOTNLM
OT  - Brain
OT  - Depression like behavior
OT  - Hippocampus
OT  - Hypothyroidism induced by thyrodectomy
EDAT- 2016/02/11 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/11 06:00
PHST- 2015/10/15 00:00 [received]
PHST- 2015/12/18 00:00 [revised]
PHST- 2016/02/03 00:00 [accepted]
PHST- 2016/02/11 06:00 [entrez]
PHST- 2016/02/11 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S0031-9384(16)30049-X [pii]
AID - 10.1016/j.physbeh.2016.02.005 [doi]
PST - ppublish
SO  - Physiol Behav. 2016 Apr 1;157:158-64. doi: 10.1016/j.physbeh.2016.02.005. Epub 
      2016 Feb 6.