PMID- 26862270
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160210
LR  - 20200930
IS  - 0971-6580 (Print)
IS  - 0976-5131 (Electronic)
IS  - 0971-6580 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Jan-Apr
TI  - Effect of Repeated Administration of Cefquinome on Biochemical and Hematological 
      Parameters in Buffalo Calves.
PG  - 110-3
LID - 10.4103/0971-6580.172267 [doi]
AB  - AIM: Cefquinome, a fourth generation of cephalosporins have been developed for 
      use in animals. Similar to other species, it may also have some adverse reactions 
      in buffalo calves at therapeutic dosage. In the present study, effect of repeated 
      administration of cefquinome on biochemical and hematological parameters was 
      studied in buffalo calves. MATERIALS AND METHODS: Animals were divided into two 
      groups having three animals in each group. Group 1 was kept as control and 
      animals of Group 2 were given cefquinome at dose rate of 2 mg.kg(-1) body weight 
      by intramuscular route for continuously 7 days. Blood samples were collected 
      daily and 3 days post treatment. RESULTS: The values of aspartate 
      aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl 
      transpeptidase (GGTP), and alkaline phosphatase (ALKP) in control animals were in 
      the range of 127.7-148.3 IU/L,49.0-55.6 IU/L, 14.0-17.3 IU/L, and 111.0-134.3 
      IU/L, respectively. The repeated administration of cefquinome did not influence 
      the plasma activities of AST, ALT, GGTP, and ALKP in treated animals. The level 
      of blood urea nitrogen (BUN) and creatinine before treatment was 14.3 +/- 0.88 
      mg/dl and1.70 +/- 0.04 mg/dl, which significantly increased on 3(rd) day (21.0 +/- 
      1.53 mg/dl) and 2(nd) day (2.33 +/- 0.07 mg/dl), respectively. Among hematological 
      parameters, there was significant variation in levels of hemoglobin (Hb), total 
      erythrocyte count (TEC), erythrocyte sedimentation rate (ESR), mean corpuscular 
      volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin 
      concentration (MCHC) in treated animals. No abnormal clinical symptoms were 
      observed in any animal. CONCLUSION: The results revealed that clinically, the 
      therapy of cefquinome may be continued up to 7 days.
FAU - Mangal, Mukesh
AU  - Mangal M
AD  - Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary 
      and Animal Sciences University, Ludhiana, Punjab, India.
FAU - Sharma, Suresh Kumar
AU  - Sharma SK
AD  - Department of Veterinary Pharmacology and Toxicology, Guru Angad Dev Veterinary 
      and Animal Sciences University, Ludhiana, Punjab, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Toxicol Int
JT  - Toxicology international
JID - 101191279
PMC - PMC4721157
OTO - NOTNLM
OT  - Biochemical effects
OT  - buffalo calves
OT  - cefquinome
OT  - hematological effects
EDAT- 2016/02/11 06:00
MHDA- 2016/02/11 06:01
PMCR- 2015/01/01
CRDT- 2016/02/11 06:00
PHST- 2016/02/11 06:00 [entrez]
PHST- 2016/02/11 06:00 [pubmed]
PHST- 2016/02/11 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - TI-22-110 [pii]
AID - 10.4103/0971-6580.172267 [doi]
PST - ppublish
SO  - Toxicol Int. 2015 Jan-Apr;22(1):110-3. doi: 10.4103/0971-6580.172267.