PMID- 26862526
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160210
LR  - 20220408
IS  - 2228-5806 (Print)
IS  - 2228-5814 (Electronic)
IS  - 2228-5806 (Linking)
VI  - 17
IP  - 4
DP  - 2016 Winter
TI  - Histological Study of Bone Marrow and Umbilical Cord Stromal Cell Transplantation 
      in Regenerating Rat Peripheral Nerve.
PG  - 668-77
AB  - OBJECTIVE: Bone marrow and umbilical cord stromal cells are multipotential stem 
      cells that have the ability to produce growth factors that play an important role 
      in survival and generation of axons. The goal of this study was to evaluate the 
      effects of the two different mesenchymal stem cells on peripheral nerve 
      regeneration. MATERIALS AND METHODS: In this experimental study, a 10 mm segment 
      of the left sciatic nerve of male Wistar rats (250-300 g) was removed with a 
      silicone tube interposed into this nerve gap. Bone marrow stromal cells (BMSCs) 
      and human umbilical cord stromal cells (HUCSCs) were respectively obtained from 
      rat and human. The cells were sepa- rately cultured and transplanted into the 
      nerve gap. The sciatic nerve regeneration was evaluated by immunohistochemistry, 
      and light and electron microscopy. Moreover, histo- morphology of the 
      gastrocnemius muscle was observed. RESULTS: The nerve regeneration in the BMSCs 
      and HUCSCs groups that had received the stem cells was significantly more 
      favorable than the control group. In addition, the BM- SCs group was 
      significantly more favorable than the HUCSCs group (P<0.05). CONCLUSION: The 
      results of this study suggest that both homograft BMSCs and het- erograft HUCSCs 
      may have the potential to regenerate peripheral nerve injury and transplantation 
      of BMSCs may be more effective than HUCSCs in rat.
FAU - Zarbakhsh, Sam
AU  - Zarbakhsh S
AD  - Research Center of Nervous System Stem Cells, Department of Anatomy, Faculty of 
      Medicine, Semnan University of Medical Sciences, Semnan, Iran.
FAU - Goudarzi, Nasim
AU  - Goudarzi N
AD  - Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Shirmohammadi, Maryam
AU  - Shirmohammadi M
AD  - Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Safari, Manouchehr
AU  - Safari M
AD  - Research Center of Nervous System Stem Cells, Department of Anatomy, Faculty of 
      Medicine, Semnan University of Medical Sciences, Semnan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20160117
PL  - Iran
TA  - Cell J
JT  - Cell journal
JID - 101566618
PMC - PMC4746417
OTO - NOTNLM
OT  - Bone Marrow Stromal Cells
OT  - Human Umbilical Cord Stromal Cells
OT  - Peripheral Nerve
OT  - Regeneration
OT  - Trans- plantation
EDAT- 2016/02/11 06:00
MHDA- 2016/02/11 06:01
PMCR- 2016/01/01
CRDT- 2016/02/11 06:00
PHST- 2014/11/25 00:00 [received]
PHST- 2015/02/05 00:00 [accepted]
PHST- 2016/02/11 06:00 [entrez]
PHST- 2016/02/11 06:00 [pubmed]
PHST- 2016/02/11 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.22074/cellj.2016.3839 [doi]
PST - ppublish
SO  - Cell J. 2016 Winter;17(4):668-77. doi: 10.22074/cellj.2016.3839. Epub 2016 Jan 
      17.