PMID- 26863345
OWN - NLM
STAT- MEDLINE
DCOM- 20170307
LR  - 20220310
IS  - 1437-4331 (Electronic)
IS  - 1434-6621 (Linking)
VI  - 54
IP  - 10
DP  - 2016 Oct 1
TI  - Osteocalcin as a potential risk biomarker for cardiovascular and metabolic 
      diseases.
PG  - 1579-87
LID - 10.1515/cclm-2015-0953 [doi]
AB  - Clear evidence supports a role for circulating and locally-produced osteocalcin 
      (OC) in the pathophysiology of cardiovascular (CV) lesions and CV risk, also in 
      combination with metabolic changes, including type 2 diabetes mellitus (T2DM). 
      Reduced plasma OC levels are associated with greater incidence of pathological CV 
      changes, like arterial and valvular calcification, coronary and carotid 
      atherosclerosis and increased carotid intima-media thickness. The actual 
      relationship between OC levels and incidence of major CV events is, however, 
      still unclear. Moreover, reduced circulating OC levels have been mostly 
      associated with insulin resistance, metabolic syndrome or T2DM, indicating 
      relevant OC actions on pancreatic beta-cells and insulin secretion and activity. 
      Based on these observations, this review article will attempt to summarize the 
      current evidence on the potential usefulness of circulating OC as a biomarker for 
      CV and metabolic risk, also evaluating the currently open issues in this area of 
      research.
FAU - Magni, Paolo
AU  - Magni P
FAU - Macchi, Chiara
AU  - Macchi C
FAU - Sirtori, Cesare R
AU  - Sirtori CR
FAU - Corsi Romanelli, Massimiliano Marco
AU  - Corsi Romanelli MM
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Clin Chem Lab Med
JT  - Clinical chemistry and laboratory medicine
JID - 9806306
RN  - 0 (Biomarkers)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Biomarkers/*metabolism
MH  - Carotid Intima-Media Thickness
MH  - Diabetes Mellitus, Type 2/*diagnosis/metabolism
MH  - Humans
MH  - Insulin Resistance
MH  - Metabolic Syndrome/*diagnosis/metabolism
MH  - Osteocalcin/*metabolism
EDAT- 2016/02/11 06:00
MHDA- 2017/03/08 06:00
CRDT- 2016/02/11 06:00
PHST- 2015/09/30 00:00 [received]
PHST- 2015/12/17 00:00 [accepted]
PHST- 2016/02/11 06:00 [entrez]
PHST- 2016/02/11 06:00 [pubmed]
PHST- 2017/03/08 06:00 [medline]
AID - /j/cclm.ahead-of-print/cclm-2015-0953/cclm-2015-0953.xml [pii]
AID - 10.1515/cclm-2015-0953 [doi]
PST - ppublish
SO  - Clin Chem Lab Med. 2016 Oct 1;54(10):1579-87. doi: 10.1515/cclm-2015-0953.