PMID- 26864027
OWN - NLM
STAT- MEDLINE
DCOM- 20160728
LR  - 20160319
IS  - 2042-7670 (Electronic)
IS  - 0042-4900 (Linking)
VI  - 178
IP  - 12
DP  - 2016 Mar 19
TI  - Comparison of commercial type 1 and type 2 PRRSV vaccines against heterologous 
      dual challenge.
PG  - 291
LID - 10.1136/vr.103529 [doi]
AB  - This study was to compare the effect of vaccination of pigs with either type 1 or 
      type 2 porcine reproductive and respiratory syndrome virus (PRRSV) against 
      heterologous dual challenge of both genotypes. Pigs were administered type 1 
      (UNISTRAIN PRRS) or type 2 (Fostera PRRS) PRRSV vaccine at 28 days of age and 
      inoculated intranasally with both genotypes at 63 days of age. Vaccination of 
      pigs with type 1 PRRSV was able to reduce the levels of type 1 but not type 2 
      PRRSV viraemia, whereas vaccination of pigs with type 2 PRRSV was able to reduce 
      the levels of type 1 and type 2 PRRSV viraemia against a dual challenge. 
      Vaccination of pigs with type 2 PRRSV significantly reduced lung lesions after 
      dual challenge compared with vaccination of pigs with type 1 PRRSV. Vaccination 
      of pigs with type 2 PRRSV induced higher numbers of type 1 and type 2 
      PRRSV-specific interferon-gamma secreting cells compared with vaccination of pigs 
      with type 1 PRRSV after dual challenge. The results of this study demonstrated 
      that vaccination of pigs with type 2 PRRSV is efficacious in protecting growing 
      pigs from respiratory disease after heterologous dual type 1 and type 2 PRRSV 
      challenge compared with vaccination of pigs with type 1 PRRSV.
CI  - British Veterinary Association.
FAU - Choi, K
AU  - Choi K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Park, C
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Jeong, J
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Kang, I
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Park, S-J
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
FAU - Chae, C
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160210
PL  - England
TA  - Vet Rec
JT  - The Veterinary record
JID - 0031164
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Genotype
MH  - Porcine Reproductive and Respiratory Syndrome/immunology/*prevention & control
MH  - Porcine respiratory and reproductive syndrome virus/genetics/*immunology
MH  - Swine
MH  - Vaccination/methods/*veterinary
MH  - Viral Vaccines/*immunology
OTO - NOTNLM
OT  - Co-infection
OT  - Genotype
OT  - Porcine reproductive and respiratory syndrome
OT  - Vaccine
EDAT- 2016/02/13 06:00
MHDA- 2016/07/29 06:00
CRDT- 2016/02/12 06:00
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/02/12 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/07/29 06:00 [medline]
AID - vr.103529 [pii]
AID - 10.1136/vr.103529 [doi]
PST - ppublish
SO  - Vet Rec. 2016 Mar 19;178(12):291. doi: 10.1136/vr.103529. Epub 2016 Feb 10.