PMID- 26865327
OWN - NLM
STAT- MEDLINE
DCOM- 20170103
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Feb 11
TI  - Hyperhomocysteinaemia is an independent risk factor of abdominal aortic aneurysm 
      in a Chinese Han population.
PG  - 17966
LID - 10.1038/srep17966 [doi]
LID - 17966
AB  - The associations between hyperhomocysteinaemia (HHcy), methylenetetrahydrofolate 
      reductase (MTHFR) C677T polymorphism, and abdominal aortic aneurysm (AAA) remain 
      controversial, with only few studies focused on these associations within the 
      Chinese population. We performed subgroup and interaction analyses in a Chinese 
      Han population to investigate these associations. In all, 155 AAA patients and 
      310 control subjects were evaluated for serum total homocysteine levels and MTHFR 
      C677T polymorphisms. Multiple logistic regression models were used to evaluate 
      the aforementioned associations. Interaction and stratified analyses were 
      conducted according to age, sex, smoking status, drinking status, and chronic 
      disease histories. The multiple logistic analyses showed a significant 
      association between HHcy and AAA but no significant association between MTHFR 
      C677T polymorphism and AAA. The interaction analysis showed that age and 
      peripheral arterial disease played an interactive role in the association between 
      HHcy and AAA, while drinking status played an interactive role in the association 
      between MTHFR C677T polymorphism and AAA. In conclusion, HHcy is an independent 
      risk factor of AAA in a Chinese Han population, especially in the elderly and 
      peripheral arterial disease subgroups. Longitudinal studies and clinical trials 
      aimed to reduce homocysteine levels are warranted to assess the causal nature of 
      these relationships.
FAU - Liu, Jie
AU  - Liu J
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Zuo, Shang Wei
AU  - Zuo SW
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Li, Yue
AU  - Li Y
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Jia, Xin
AU  - Jia X
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Jia, Sen Hao
AU  - Jia SH
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Zhang, Tao
AU  - Zhang T
AD  - Department of Vascular Surgery, Peking University People's Hospital. Beijing 
      100044, China.
FAU - Song, Yu Xiang
AU  - Song YX
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Wei, Ying Qi
AU  - Wei YQ
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University Health Science Center, Beijing 100191, China.
FAU - Xiong, Jiang
AU  - Xiong J
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
FAU - Hu, Yong Hua
AU  - Hu YH
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking 
      University Health Science Center, Beijing 100191, China.
FAU - Guo, Wei
AU  - Guo W
AD  - Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, 
      Beijing 100853, China.
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160211
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - EC 1.5.1.20 (MTHFR protein, human)
RN  - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2))
SB  - IM
MH  - Aged
MH  - *Aortic Aneurysm, Abdominal/blood/ethnology/genetics
MH  - *Asian People/ethnology/genetics
MH  - Case-Control Studies
MH  - China/ethnology
MH  - Female
MH  - Homocysteine/blood/genetics
MH  - Humans
MH  - *Hyperhomocysteinemia/blood/ethnology/genetics
MH  - Male
MH  - *Methylenetetrahydrofolate Reductase (NADPH2)/blood/genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Risk Factors
PMC - PMC4750057
EDAT- 2016/02/13 06:00
MHDA- 2017/01/04 06:00
PMCR- 2016/02/11
CRDT- 2016/02/12 06:00
PHST- 2015/07/02 00:00 [received]
PHST- 2015/11/09 00:00 [accepted]
PHST- 2016/02/12 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2017/01/04 06:00 [medline]
PHST- 2016/02/11 00:00 [pmc-release]
AID - srep17966 [pii]
AID - 10.1038/srep17966 [doi]
PST - epublish
SO  - Sci Rep. 2016 Feb 11;6:17966. doi: 10.1038/srep17966.