PMID- 26866009
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160211
LR  - 20200930
IS  - 2251-7006 (Print)
IS  - 2251-7014 (Electronic)
IS  - 2251-7006 (Linking)
VI  - 7
IP  - 6
DP  - 2015 Nov
TI  - Human Leukocyte Antigen Alleles and Cytomegalovirus Infection After Renal 
      Transplantation.
PG  - e31635
LID - 10.5812/numonthly.31635 [doi]
LID - e31635
AB  - BACKGROUND: Several studies have been conducted on the relationship between a 
      number of human leukocyte antigen (HLA) alleles and cytomegalovirus infection 
      (CMV), in kidney transplant recipients, after transplantation. However, only a 
      limited number of HLAs have been investigated, so far, and the results have been 
      contradictory. OBJECTIVES: This study aimed to investigate the relationship 
      between 59 HLA alleles and the CMV infection, in transplant recipients, after 
      kidney transplantation. PATIENTS AND METHODS: This retrospective cohort study was 
      conducted on 200 patients, receiving a kidney transplant, in Baqiyatallah 
      Hospital, in Tehran, during 2013. Throughout a one-year follow-up of kidney 
      transplant recipients, in case of detecting the CMV antigen in patients' blood, 
      at any time, they were placed in the group of patients with CMV infection, 
      whereas, if no CMV-specific antigen was developed, over a year, patients were 
      placed in the group of patients without CMV infection, after transplantation. 
      This study investigated the relationship between CMV infection in kidney 
      transplant recipients and 59 HLA alleles, including 14 HLA-A, 28 HLA-B, and 17 
      HLA-DRB1 cases. RESULTS: Of all participants, 104 patients (52%) were diagnosed 
      with CMV infection. There was no significant difference between the two groups, 
      with and without CMV infection, in terms of patient's characteristics. The CMV 
      infection, in patients receiving a transplanted organ from deceased donor, was 
      significantly more prevalent than in those receiving kidney transplant from 
      living donor (63% vs. 39%, respectively, P = 0.001). Recipients with HLA-B44 were 
      more infected with CMV compared with patients without this allele (80% vs. 50%, 
      respectively, P = 0.024); on the contrary, kidney recipients with HLA-DRB1-1 were 
      less infected with CMV than patients without this allele (31% vs. 55%, 
      respectively, P = 0.020). There was no significant relationship between CMV 
      infection and other HLA alleles. Results of multivariate logistic regression 
      analysis showed that deceased donor renal transplantation (OR = 3.018, 95%CI: 
      1.662 - 5.480, P < 0.001), presence of HLA-B44 (OR = 4.764, 95%CI: 1.259 - 
      18.032, P = 0.022) and lack of HLA-B8 (OR = 3.246, 95%CI: 1.030 - 10.230, P = 
      0.044) were the independent risk factors for developing CMV infection, after 
      kidney transplantation. CONCLUSIONS: The findings of this study showed that 
      deceased donor renal transplantation and the presence of HLA-B44 can make the 
      kidney recipient susceptible to CMV infection after kidney transplantation; on 
      the other hand, the presence of HLA-B8 can have a protective effect.
FAU - Futohi, Farzaneh
AU  - Futohi F
AD  - Department of Nephrology, Rajaie Cardiovascular Medical and Research Center, 
      Tehran, IR Iran.
FAU - Saber, Azadeh
AU  - Saber A
AD  - Department of Nephrology, Kerman University of Medical Sciences, Kerman, IR Iran.
FAU - Nemati, Eglim
AU  - Nemati E
AD  - Department of Nephrology, Nephrology and Urology Research Center, Baqiyatallah 
      University of Medical Sciences, Tehran, IR Iran.
FAU - Einollahi, Behzad
AU  - Einollahi B
AD  - Department of Nephrology, Nephrology and Urology Research Center, Baqiyatallah 
      University of Medical Sciences, Tehran, IR Iran.
FAU - Rostami, Zohre
AU  - Rostami Z
AD  - Department of Nephrology, Nephrology and Urology Research Center, Baqiyatallah 
      University of Medical Sciences, Tehran, IR Iran.
LA  - eng
PT  - Journal Article
DEP - 20151129
PL  - Netherlands
TA  - Nephrourol Mon
JT  - Nephro-urology monthly
JID - 101578609
PMC - PMC4744639
OTO - NOTNLM
OT  - Cytomegalovirus
OT  - Cytomegalovirus Infections
OT  - Human Leukocyte Antigen
OT  - Kidney Transplantation
EDAT- 2016/02/13 06:00
MHDA- 2016/02/13 06:01
PMCR- 2015/11/01
CRDT- 2016/02/12 06:00
PHST- 2015/07/19 00:00 [received]
PHST- 2015/08/30 00:00 [revised]
PHST- 2015/09/12 00:00 [accepted]
PHST- 2016/02/12 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/02/13 06:01 [medline]
PHST- 2015/11/01 00:00 [pmc-release]
AID - 10.5812/numonthly.31635 [doi]
PST - epublish
SO  - Nephrourol Mon. 2015 Nov 29;7(6):e31635. doi: 10.5812/numonthly.31635. 
      eCollection 2015 Nov.