PMID- 26866849
OWN - NLM
STAT- MEDLINE
DCOM- 20170403
LR  - 20170403
IS  - 2153-7933 (Electronic)
IS  - 2153-7658 (Linking)
VI  - 6
IP  - 2
DP  - 2016 Jun
TI  - Effect of Therapeutic Hypothermia on Survival and Neurologic Outcome in the 
      Elderly.
PG  - 71-5
LID - 10.1089/ther.2015.0030 [doi]
AB  - Old age is considered a negative prognostic factor after out-of-hospital cardiac 
      arrest (OHCA). The purpose of this study was to assess the benefit of therapeutic 
      hypothermia (TH) on survival and neurologic outcome in the elderly. This is a 
      retrospective study of patients treated for OHCA from April 2011 to August 2013 
      in a regional cardiac system. Patients with return of spontaneous circulation 
      (ROSC) are directed to designated cardiac receiving centers with established TH 
      protocols. The decision to initiate TH is determined by the treating physician. 
      All patients 65 years or older were identified. Patients were excluded if awake 
      and responsive in the emergency department, died before hospital admission, or 
      had preexisting coma. The adjusted odds ratio for survival with good neurologic 
      outcome (defined as cerebral performance category [CPC] 1 or 2) was calculated 
      for patients who received TH compared to a reference group without TH. There were 
      1612 patients, of whom 552 (34%) received TH. Median age was 78 (inter-quartile 
      range [IQR] 71-85); 56% was male. 493 (31%) patients survived to hospital 
      discharge, 266 (17%) with CPC of 1 or 2. Of 1292 patients considered for TH, 192 
      (25%) of 552 patients who received TH survived to hospital discharge and 97 (18%) 
      with good neurologic outcome compared to 150 (20%) and 57 (8%), respectively, 
      without TH. The adjusted odds ratio for survival with good neurologic outcome for 
      TH was 2.0 (95% CI 1.3-3.3). TH is associated with improved neurologic outcome in 
      the elderly population.
FAU - Bosson, Nichole E
AU  - Bosson NE
AD  - 1 Department of Emergency Medicine, Harbor-UCLA Medical Center, Los Angeles 
      Biomedical Research Institute at Harbor-UCLA , Torrance, California.
AD  - 2 David Geffen School of Medicine at UCLA , Los Angeles, California.
AD  - 3 Los Angeles County Emergency Medical Services Agency , Santa Fe Springs, 
      California.
FAU - Kaji, Amy H
AU  - Kaji AH
AD  - 1 Department of Emergency Medicine, Harbor-UCLA Medical Center, Los Angeles 
      Biomedical Research Institute at Harbor-UCLA , Torrance, California.
AD  - 2 David Geffen School of Medicine at UCLA , Los Angeles, California.
FAU - Koenig, William J
AU  - Koenig WJ
AD  - 3 Los Angeles County Emergency Medical Services Agency , Santa Fe Springs, 
      California.
FAU - Niemann, James T
AU  - Niemann JT
AD  - 1 Department of Emergency Medicine, Harbor-UCLA Medical Center, Los Angeles 
      Biomedical Research Institute at Harbor-UCLA , Torrance, California.
AD  - 2 David Geffen School of Medicine at UCLA , Los Angeles, California.
LA  - eng
PT  - Journal Article
DEP - 20160211
PL  - United States
TA  - Ther Hypothermia Temp Manag
JT  - Therapeutic hypothermia and temperature management
JID - 101543518
SB  - IM
MH  - Aged
MH  - California/epidemiology
MH  - Cardiopulmonary Resuscitation/methods
MH  - Female
MH  - Humans
MH  - *Hypothermia, Induced/adverse effects/methods
MH  - Male
MH  - *Nervous System Diseases/diagnosis/etiology/prevention & control
MH  - Neurologic Examination/methods
MH  - *Out-of-Hospital Cardiac Arrest/complications/mortality/therapy
MH  - Retrospective Studies
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2016/02/13 06:00
MHDA- 2017/04/04 06:00
CRDT- 2016/02/12 06:00
PHST- 2016/02/12 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2017/04/04 06:00 [medline]
AID - 10.1089/ther.2015.0030 [doi]
PST - ppublish
SO  - Ther Hypothermia Temp Manag. 2016 Jun;6(2):71-5. doi: 10.1089/ther.2015.0030. 
      Epub 2016 Feb 11.