PMID- 26869904 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20160212 LR - 20200930 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 10 DP - 2016 TI - The Interface between Neuroscience and Neuro-Psychoanalysis: Focus on Brain Connectivity. PG - 20 LID - 10.3389/fnhum.2016.00020 [doi] LID - 20 AB - Over the past 20 years, the advent of advanced techniques has significantly enhanced our knowledge on the brain. Yet, our understanding of the physiological and pathological functioning of the mind is still far from being exhaustive. Both the localizationist and the reductionist neuroscientific approaches to psychiatric disorders have proven to be largely unsatisfactory and are outdated. Accruing evidence suggests that psychoanalysis can engage the neurosciences in a productive and mutually enriching dialogue that may further our understanding of psychiatric disorders. In particular, advances in brain connectivity research have provided evidence supporting the convergence of neuroscientific findings and psychoanalysis and helped characterize the circuitry and mechanisms that underlie higher brain functions. In the present paper we discuss how knowledge on brain connectivity can impact neuropsychoanalysis, with a particular focus on schizophrenia. Brain connectivity studies in schizophrenic patients indicate complex alterations in brain functioning and circuitry, with particular emphasis on the role of cortical midline structures (CMS) and the default mode network (DMN). These networks seem to represent neural correlates of psychodynamic concepts central to the understanding of schizophrenia and of core psychopathological alterations of this disorder (i.e., ego disturbances and impaired primary process thinking). FAU - Salone, Anatolia AU - Salone A AD - Department of Neuroscience, Imaging and Clinical Sciences and Institute for Advanced Biomedical Technologies-ITAB, University G. d'AnnunzioChieti-Pescara, Italy; Institute of Psychiatry, University G. d'AnnunzioChieti-Pescara, Italy. FAU - Di Giacinto, Alessandra AU - Di Giacinto A AD - Department of Neuroscience, Imaging and Clinical Sciences and Institute for Advanced Biomedical Technologies-ITAB, University G. d'AnnunzioChieti-Pescara, Italy; Institute of Psychiatry, University G. d'AnnunzioChieti-Pescara, Italy. FAU - Lai, Carlo AU - Lai C AD - Dynamic and Clinical Psychology, Sapienza University of Rome Rome, Italy. FAU - De Berardis, Domenico AU - De Berardis D AD - Institute of Psychiatry, University G. d'AnnunzioChieti-Pescara, Italy; National Health Service (NHS), Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital "G. Mazzini"Teramo, Italy. FAU - Iasevoli, Felice AU - Iasevoli F AD - Department of Neuroscience, Reproductive Sciences and Odontostomatology, Federico II University of Naples Naples, Italy. FAU - Fornaro, Michele AU - Fornaro M AD - New York State Psychiatric Institute (NYSPI), Columbia University New York, NY, USA. FAU - De Risio, Luisa AU - De Risio L AD - Department of Neuroscience, Institute of Psychiatry and Clinical Psychology, Catholic University of the Sacred Heart Rome, Italy. FAU - Santacroce, Rita AU - Santacroce R AD - Department of Neuroscience, Imaging and Clinical Sciences and Institute for Advanced Biomedical Technologies-ITAB, University G. d'AnnunzioChieti-Pescara, Italy; Institute of Psychiatry, University G. d'AnnunzioChieti-Pescara, Italy. FAU - Martinotti, Giovanni AU - Martinotti G AD - Department of Neuroscience, Imaging and Clinical Sciences and Institute for Advanced Biomedical Technologies-ITAB, University G. d'AnnunzioChieti-Pescara, Italy; Institute of Psychiatry, University G. d'AnnunzioChieti-Pescara, Italy. FAU - Giannantonio, Massimo Di AU - Giannantonio MD AD - Department of Neuroscience, Imaging and Clinical Sciences and Institute for Advanced Biomedical Technologies-ITAB, University G. d'AnnunzioChieti-Pescara, Italy; Institute of Psychiatry, University G. d'AnnunzioChieti-Pescara, Italy. LA - eng PT - Journal Article PT - Review DEP - 20160203 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC4737882 OTO - NOTNLM OT - connectivity OT - neuropsychoanalysis OT - neuroscience OT - schizophrenia OT - self OT - unconscious EDAT- 2016/02/13 06:00 MHDA- 2016/02/13 06:01 PMCR- 2016/01/01 CRDT- 2016/02/13 06:00 PHST- 2014/08/06 00:00 [received] PHST- 2016/01/14 00:00 [accepted] PHST- 2016/02/13 06:00 [entrez] PHST- 2016/02/13 06:00 [pubmed] PHST- 2016/02/13 06:01 [medline] PHST- 2016/01/01 00:00 [pmc-release] AID - 10.3389/fnhum.2016.00020 [doi] PST - epublish SO - Front Hum Neurosci. 2016 Feb 3;10:20. doi: 10.3389/fnhum.2016.00020. eCollection 2016.