PMID- 26869922
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160212
LR  - 20210105
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 8
DP  - 2016
TI  - Aberrant Functional Connectivity and Structural Atrophy in Subcortical Vascular 
      Cognitive Impairment: Relationship with Cognitive Impairments.
PG  - 14
LID - 10.3389/fnagi.2016.00014 [doi]
LID - 14
AB  - Abnormal structures in the cortical and subcortical regions have been identified 
      in subcortical vascular cognition impairment (SVCI). However, little is known 
      about the functional alterations in SVCI, and no study refers to the functional 
      connectivity in the prefrontal and subcortical regions in this context. The 
      medial prefrontal cortex (MPFC) is an important region of the executive network 
      and default mode network, and the subcortical thalamus plays vital roles in 
      mediating or modulating these two networks. To investigate both thalamus- and 
      MPFC-related functional connectivity as well as its relationship with cognition 
      in SVCI, 32 SVCI patients and 23 control individuals were administered 
      neuropsychological assessments. They also underwent structural and functional 
      magnetic resonance imaging scans. Voxel-based morphometry and functional 
      connectivity analysis were performed to detect gray matter (GM) atrophy and to 
      characterize the functional alterations in the thalamus and the MPFC. For 
      structural data, we observed that GM atrophy was distributed in both cortical 
      regions and subcortical areas. For functional data, we observed that the thalamus 
      functional connectivity in SVCI was significantly decreased in several cortical 
      regions [i.e., the orbitofrontal lobe (OFL)], which are mainly involved in 
      executive function and memory function. However, connectivity was increased in 
      several frontal regions (i.e., the inferior frontal gyrus), which may be induced 
      by the compensatory recruitment of the decreased functional connectivity. The 
      MPFC functional connectivity was also decreased in executive- and memory-related 
      regions (i.e., the anterior cingulate cortex) along with a motor region (i.e., 
      the supplementary motor area). In addition, the cognitive performance was closely 
      correlated with functional connectivity between the left thalamus and the left 
      OFL in SVCI. The present study, thus, provides evidence for an association 
      between structural and functional alterations, and sheds light on the underlying 
      neural mechanisms of executive dysfunction in SVCI.
FAU - Zhou, Xia
AU  - Zhou X
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Hu, Xiaopeng
AU  - Hu X
AD  - Department of Radiology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Zhang, Chao
AU  - Zhang C
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Wang, Haibao
AU  - Wang H
AD  - Department of Radiology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Zhu, Xiaoqun
AU  - Zhu X
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Xu, Liyan
AU  - Xu L
AD  - Department of Radiology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Sun, Zhongwu
AU  - Sun Z
AD  - Department of Neurology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
FAU - Yu, Yongqiang
AU  - Yu Y
AD  - Department of Radiology, The First Affiliated Hospital of Anhui Medical 
      University , Anhui , China.
LA  - eng
PT  - Journal Article
DEP - 20160202
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4736471
OTO - NOTNLM
OT  - MPFC
OT  - functional connectivity
OT  - gray matter atrophy
OT  - resting-state fMRI
OT  - thalamus
OT  - vascular cognition impairment
EDAT- 2016/02/13 06:00
MHDA- 2016/02/13 06:01
PMCR- 2016/01/01
CRDT- 2016/02/13 06:00
PHST- 2015/09/14 00:00 [received]
PHST- 2016/01/15 00:00 [accepted]
PHST- 2016/02/13 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/02/13 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2016.00014 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2016 Feb 2;8:14. doi: 10.3389/fnagi.2016.00014. eCollection 
      2016.