PMID- 26870045
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160212
LR  - 20190109
IS  - 1664-3224 (Print)
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 7
DP  - 2016
TI  - Alloantibody Generation and Effector Function Following Sensitization to Human 
      Leukocyte Antigen.
PG  - 30
LID - 10.3389/fimmu.2016.00030 [doi]
LID - 30
AB  - Allorecognition is the activation of the adaptive immune system to foreign human 
      leukocyte antigen (HLA) resulting in the generation of alloantibodies. Due to a 
      high polymorphism, foreign HLA is recognized by the immune system following 
      transplant, transfusion, or pregnancy resulting in the formation of the germinal 
      center and the generation of long-lived alloantibody-producing memory B cells. 
      Alloantibodies recognize antigenic epitopes displayed by the HLA molecule on the 
      transplanted allograft and contribute to graft damage through multiple 
      mechanisms, including (1) activation of the complement cascade resulting in the 
      formation of the MAC complex and inflammatory anaphylatoxins, (2) transduction of 
      intracellular signals leading to cytoskeletal rearrangement, growth, and 
      proliferation of graft vasculature, and (3) immune cell infiltration into the 
      allograft via FcgammaR interactions with the FC portion of the antibody. This review 
      focuses on the generation of HLA alloantibody, routes of sensitization, 
      alloantibody specificity, and mechanisms of antibody-mediated graft damage.
FAU - Hickey, Michelle J
AU  - Hickey MJ
AD  - Department of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, 
      University of California Los Angeles , Los Angeles, CA , USA.
FAU - Valenzuela, Nicole M
AU  - Valenzuela NM
AD  - Department of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, 
      University of California Los Angeles , Los Angeles, CA , USA.
FAU - Reed, Elaine F
AU  - Reed EF
AD  - Department of Pathology and Laboratory Medicine, UCLA Immunogenetics Center, 
      University of California Los Angeles , Los Angeles, CA , USA.
LA  - eng
GR  - R56 AI042819/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20160204
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC4740371
OTO - NOTNLM
OT  - Fc receptor
OT  - HLA antibody
OT  - allorecognition
OT  - complement
OT  - endothelium
OT  - human leukocyte antigen
OT  - non-HLA antibody
OT  - transplant
EDAT- 2016/02/13 06:00
MHDA- 2016/02/13 06:01
PMCR- 2016/01/01
CRDT- 2016/02/13 06:00
PHST- 2015/11/18 00:00 [received]
PHST- 2016/01/20 00:00 [accepted]
PHST- 2016/02/13 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/02/13 06:01 [medline]
PHST- 2016/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2016.00030 [doi]
PST - epublish
SO  - Front Immunol. 2016 Feb 4;7:30. doi: 10.3389/fimmu.2016.00030. eCollection 2016.