PMID- 26870282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1792-1074 (Print)
IS  - 1792-1082 (Electronic)
IS  - 1792-1074 (Linking)
VI  - 11
IP  - 1
DP  - 2016 Jan
TI  - Fusion of platelet-derived growth factor receptor beta to CEV14 gene in chronic 
      myelomonocytic leukemia: A case report and review of the literature.
PG  - 770-774
AB  - Myeloid tumor possessing platelet-derived growth factor receptor beta (PDGFRbeta) gene 
      rearrangement is a rare hematological malignancy, which presents with typical 
      characteristics of myeloid proliferation disorders and eosinophilia. In the 
      present study, an elderly chronic myelomonocytic leukemia patient was diagnosed 
      with chromosome rearrangement. Fluorescence in situ hybridization (FISH) was 
      conducted with a PDGFRbeta isolate probe, and gene translocation between PDGFRbeta on 
      chromosome 5 and genes on the chromosomes of group D (13-15) was detected. 
      Karyotype analysis revealed a chromosome 5 break, and PDGFRbeta-thyroid hormone 
      receptor interactor 11 (CEV14) gene fusion was confirmed via reverse 
      transcription-polymerase chain reaction (RT-PCR), which additionally revealed the 
      chromosome rearrangement t(5;14)(q33;q32). Due to the correlation between 
      PDGFRbeta-CEV14 expression and effectiveness of treatment with tyrosine kinase 
      inhibitors, this fusion gene is considered to be an oncogene. In the present 
      study, an elderly patient was diagnosed with a myeloid tumor associated with the 
      fusion gene PDGFRbeta-CEV14, using the methods of FISH and RT-PCR. These methods 
      were confirmed to be of significant value in improving diagnosis, guiding 
      treatment and increasing the cure rate of patients, due to their ability to 
      detect multiple rearrangement genes associated with PDGFRbeta in myelodysplastic and 
      myeloproliferative neoplasms.
FAU - Gong, Sheng-Lan
AU  - Gong SL
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
FAU - Guo, Meng-Qiao
AU  - Guo MQ
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
FAU - Tang, Gu-Sheng
AU  - Tang GS
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
FAU - Zhang, Chun-Ling
AU  - Zhang CL
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
FAU - Qiu, Hui-Ying
AU  - Qiu HY
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
FAU - Hu, Xiao-Xia
AU  - Hu XX
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
FAU - Yang, Jian-Min
AU  - Yang JM
AD  - Department of Hematology, Changhai Hospital, Second Military Medical University, 
      Shanghai 200433, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20151118
PL  - Greece
TA  - Oncol Lett
JT  - Oncology letters
JID - 101531236
PMC - PMC4727129
OTO - NOTNLM
OT  - chromosome rearrangement
OT  - chronic myelomonocytic leukemia
OT  - gene fusion
OT  - platelet-derived growth factor receptor beta
EDAT- 2016/02/13 06:00
MHDA- 2016/02/13 06:01
PMCR- 2015/11/18
CRDT- 2016/02/13 06:00
PHST- 2015/01/28 00:00 [received]
PHST- 2015/09/14 00:00 [accepted]
PHST- 2016/02/13 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/02/13 06:01 [medline]
PHST- 2015/11/18 00:00 [pmc-release]
AID - OL-0-0-3949 [pii]
AID - 10.3892/ol.2015.3949 [doi]
PST - ppublish
SO  - Oncol Lett. 2016 Jan;11(1):770-774. doi: 10.3892/ol.2015.3949. Epub 2015 Nov 18.