PMID- 26871790
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20221207
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 6
DP  - 2016 Feb
TI  - Folic Acid and Vitamins D and B12 Correlate With Homocysteine in Chinese Patients 
      With Type-2 Diabetes Mellitus, Hypertension, or Cardiovascular Disease.
PG  - e2652
LID - 10.1097/MD.0000000000002652 [doi]
LID - e2652
AB  - Elevated serum homocysteine has been shown to be a risk factor for hypertension, 
      cardiovascular disease (CVD), and type-2 diabetes mellitus (T2DM).We 
      characterized the relationships between the serum levels of homocysteine, folic 
      acid, and vitamins D2, D3, and B12 in patients with T2DM, CVD, and hypertension 
      in Shanghai, China. The levels of these serum biochemical markers were determined 
      for 9311 Chinese patients (mean age: 79.50 +/- 13.26 years) with T2DM (N = 839), 
      hypertension (N = 490), or CVD (N = 7925). The demographic and serum biochemical 
      data were compared using an analysis of variance. We performed stratified 
      analyses using Pearson linear regression to investigate correlations between the 
      different variables in the T2DM, CVD, and hypertension groups and in patients 
      aged < 50, 50 to 64, 65 to 80, and >/=80 years. A subgroup analysis was also 
      performed to identify correlations between the serum biochemical markers. 
      Stratified chi-squared analyses were performed based on the levels of folic acid 
      and total vitamin D.In all 3 patient groups, elevated levels of vitamin D2 and 
      homocysteine were observed, whereas the levels of folic acid and vitamins D3 and 
      B12 were lower than the reference range for each serum marker (P < 0.05 for all). 
      The linear regression and stratified analyses showed that the highest levels of 
      folic acid and vitamins D2 and D3 correlated with the lowest level of 
      homocysteine in T2DM, CVD, and hypertension patients (P < 0.05 for all), whereas 
      the highest level of vitamin B12 correlated with a lowest level of homocysteine 
      in CVD patients only (P < 0.05).Our results indicate that the contributions of 
      both vitamin D2 and vitamin D3 should be considered in investigations of the 
      effects of vitamin D supplements in T2DM, CVD, and hypertension patients. Our 
      findings warrant future studies of the benefits of vitamin D and folic acid 
      supplements for reducing the risk of T2DM, CVD, and hypertension in elderly 
      Chinese people, as well as the benefits of vitamin B12 supplements for reducing 
      the risk of CVD alone.
FAU - Mao, Xudong
AU  - Mao X
AD  - From the Department of Geriatrics (XM, YQ, RX, QG, YH); Central Laboratory (SL); 
      Department of Endocrinology, Shanghai Xuhui Central Hospital, Shanghai Clinical 
      Center, Chinese Academy of Sciences (CL, XD, ZL, RN); Department of Cardiology, 
      Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine, 
      (XX); and Institute of Radiation Medicine, Shanghai Medical College, Fudan 
      University, Shanghai, China (HW).
FAU - Xing, Xubin
AU  - Xing X
FAU - Xu, Rong
AU  - Xu R
FAU - Gong, Qing
AU  - Gong Q
FAU - He, Yue
AU  - He Y
FAU - Li, Shuijun
AU  - Li S
FAU - Wang, Hongfu
AU  - Wang H
FAU - Liu, Cong
AU  - Liu C
FAU - Ding, Xin
AU  - Ding X
FAU - Na, Rishu
AU  - Na R
FAU - Liu, Zhiwen
AU  - Liu Z
FAU - Qu, Yi
AU  - Qu Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0LVT1QZ0BA (Homocysteine)
RN  - 1406-16-2 (Vitamin D)
RN  - 935E97BOY8 (Folic Acid)
RN  - P6YC3EG204 (Vitamin B 12)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People
MH  - Cardiovascular Diseases/*blood/complications
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Dietary Supplements
MH  - Female
MH  - Folic Acid/*blood
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hypertension/*blood/complications
MH  - Male
MH  - Vitamin B 12/*blood
MH  - Vitamin D/*blood
PMC - PMC4753885
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/02/13 06:00
MHDA- 2016/07/01 06:00
PMCR- 2016/02/12
CRDT- 2016/02/13 06:00
PHST- 2016/02/13 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
PHST- 2016/02/12 00:00 [pmc-release]
AID - 00005792-201602090-00032 [pii]
AID - 10.1097/MD.0000000000002652 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Feb;95(6):e2652. doi: 10.1097/MD.0000000000002652.