PMID- 26871799
OWN - NLM
STAT- MEDLINE
DCOM- 20160630
LR  - 20221005
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 95
IP  - 6
DP  - 2016 Feb
TI  - Preoperative Neutrophil-to-lymphocyte Ratio Predicts Long-term Survival in 
      Patients Undergoing Total Laryngectomy With Advanced Laryngeal Squamous Cell 
      Carcinoma: A Single-center Retrospective Study.
PG  - e2689
LID - 10.1097/MD.0000000000002689 [doi]
LID - e2689
AB  - There is increasing evidence that the neutrophil-to-lymphocyte ratio (NLR) is a 
      stage-independent predictor of poor outcome in patients with cancer. The purpose 
      of this study was to investigate the association between cancer-specific survival 
      (CSS), overall survival (OS), and the preoperative NLR in patients with advanced 
      laryngeal squamous cell carcinoma (LSCC) undergoing total laryngectomy (TL).All 
      patients with a new diagnosis of advanced laryngeal cancer (stages III and IV) 
      presenting at the Department of Head and Neck Oncology, Sun Yat-sen University 
      Cancer Center between January 1990 and July 2010 (n = 420) were included. To 
      evaluate the independent prognostic relevance of the NLR, univariate and 
      multivariate Cox regression models were used. CSS and OS were estimated using the 
      Kaplan-Meier method.Four-hundred twenty patients were enrolled in this study. 
      Patients with an NLR >/=2.59 showed a significantly lower CSS (P = .014) and OS 
      (P = .032) than patients with an NLR <2.59. The Cox proportional multivariate 
      hazard model showed that a higher preoperative NLR was independently correlated 
      with a poor CSS and OS, with hazard ratios of 1.42 (95% confidence interval [CI] 
      1.06-1.91, P = .018) and 1.31 (95% CI 1.00-1.71, P = .046), respectively.The NLR 
      may be an independent prognostic marker for CSS and OS in patients with advanced 
      LSCC undergoing TL.
FAU - Fu, Yan
AU  - Fu Y
AD  - From the Department of Head and Neck Oncology, Sun Yat-sen University Cancer 
      Center; State Key Laboratory of Oncology in South China; Collaborative Innovation 
      Center for Cancer Medicine, Guangzhou, China.
FAU - Liu, Weiwei
AU  - Liu W
FAU - OuYang, Dian
AU  - OuYang D
FAU - Yang, Ankui
AU  - Yang A
FAU - Zhang, Quan
AU  - Zhang Q
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*blood/mortality/*surgery
MH  - Female
MH  - Head and Neck Neoplasms/*blood/mortality/*surgery
MH  - Humans
MH  - Laryngeal Neoplasms/*blood/mortality/*surgery
MH  - *Laryngectomy
MH  - Leukocyte Count
MH  - *Lymphocytes
MH  - Male
MH  - Middle Aged
MH  - *Neutrophils
MH  - Predictive Value of Tests
MH  - Preoperative Period
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Survival Rate
MH  - Time Factors
PMC - PMC4753894
COIS- The authors have no conflicts of interest to disclose.
EDAT- 2016/02/13 06:00
MHDA- 2016/07/01 06:00
PMCR- 2016/02/12
CRDT- 2016/02/13 06:00
PHST- 2016/02/13 06:00 [entrez]
PHST- 2016/02/13 06:00 [pubmed]
PHST- 2016/07/01 06:00 [medline]
PHST- 2016/02/12 00:00 [pmc-release]
AID - 00005792-201602090-00041 [pii]
AID - 10.1097/MD.0000000000002689 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2016 Feb;95(6):e2689. doi: 10.1097/MD.0000000000002689.