PMID- 26872616
OWN - NLM
STAT- MEDLINE
DCOM- 20161019
LR  - 20220410
IS  - 1472-6823 (Electronic)
IS  - 1472-6823 (Linking)
VI  - 16
DP  - 2016 Feb 12
TI  - Results of a prospective multicenter neuroendocrine tumor registry reporting on 
      clinicopathologic characteristics of Greek patients.
PG  - 8
LID - 10.1186/s12902-016-0089-7 [doi]
LID - 8
AB  - BACKGROUND: The rare incidence of neuroendocrine neoplasms (NENs) has contributed 
      to a paucity of large epidemiologic studies of patients with this condition. We 
      investigated the occurrence and clinicopathologic features of NENs in Greece. 
      METHODS: Between October 2010 and November 2012 we collected data on 246 newly 
      diagnosed patients from a broad-based multi-institutional registry that comprises 
      eight academic and hospital sites in Greece. The WHO 2010 pathologic 
      classification and the 7th AJCC Staging system was applied in all cases. RESULTS: 
      Of all patients 94 % had a sporadic and 6 % a multiple endocrine neoplasia tumor; 
      63.4 % were gastroenteropancreatic-(GEP)-NENs, 17.9 % Head & Neck NENs, 9.8 % 
      NENs of Unknown Primary, 6.5 % Lung NENs and 2.4 % Pheochromocytomas. Gastric and 
      pancreatic NENs were the most common primary sites. Poorly differentiated 
      neuroendocrine carcinomas (NEC) were 9.3 %, all sporadic. Fifteen percent of 
      patients were asymptomatic at presentation, 24 % had a first symptom of the 
      disease related to endocrine syndrome and 61 % had symptoms related to locally 
      advanced or metastatic disease. Metastatic disease was established in 25 % of 
      tumors most frequently in the GEP NEN group. Findings are presented according to 
      Ki-67 distribution. MRI had a higher diagnostic positive yield than Octreoscan. 
      Somatostatin analogs, lanreotide and octreotide acetate, were prescribed at 38.5 
      & 61.5 % of NEN patients respectively and were found to be equally effective at 
      providing symptomatic relief. CONCLUSIONS: This is to our knowledge the first 
      study of a Greek tumor registry and one of the few European Registries providing 
      information regarding clinicopathologic characteristics and therapies in patients 
      with neuroendocrine tumors of various origin sites, beyond GEP NENs.
FAU - Nikou, George C
AU  - Nikou GC
AD  - Neuroendocrinology Section, 1st Department of Propaedeutic Internal Medicine, 
      Laiko University Hospital, Athens, Greece.
FAU - Pazaitou-Panayiotou, Kalliopi
AU  - Pazaitou-Panayiotou K
AD  - Unit of Endocrinology and Endocrine Oncology, Theagenio Cancer Hospital, 
      Thessaloniki, Greece.
FAU - Dimitroulopoulos, Dimitrios
AU  - Dimitroulopoulos D
AD  - Gastroenterology Department, Agios Savas Cancer Hospital, Alphathens, Greece.
FAU - Alexandrakis, Georgios
AU  - Alexandrakis G
AD  - Gastroenterology Department, NuIotaMuTauS Hospital, Alphathens, Greece.
FAU - Papakostas, Pavlos
AU  - Papakostas P
AD  - Oncology Department, Hippokrateion Hospital, Athens, Greece.
FAU - Vaslamatzis, Michalis
AU  - Vaslamatzis M
AD  - Oncology Department, Evangelismos Hospital, Athens, Greece.
FAU - Kaldrymidis, Philippos
AU  - Kaldrymidis P
AD  - Department of Endocrinology, Metaxa Cancer Hospital, Piraeus, Greece.
FAU - Markussis, Vyron
AU  - Markussis V
AD  - Ipsen epe, Athens, Greece.
FAU - Koumarianou, Anna
AU  - Koumarianou A
AD  - Hematology-Oncology Unit, Fourth Department of Internal Medicine, Attikon 
      University Hospital, Medical School, National and Kapodestrian University of 
      Athens, Rimini 1, 12462, Haidari, Athens, Greece. akoumari@yahoo.com.
CN  - "G-NET-Registry" investigators
LA  - eng
PT  - Journal Article
DEP - 20160212
PL  - England
TA  - BMC Endocr Disord
JT  - BMC endocrine disorders
JID - 101088676
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Gastrointestinal Neoplasms/epidemiology/pathology
MH  - Greece/epidemiology
MH  - Head and Neck Neoplasms/epidemiology/pathology
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Neuroendocrine Tumors/*epidemiology/pathology
MH  - Pancreatic Neoplasms/epidemiology/pathology
MH  - Prospective Studies
MH  - Registries/*statistics & numerical data
MH  - Young Adult
PMC - PMC4752769
EDAT- 2016/02/14 06:00
MHDA- 2016/12/30 06:00
PMCR- 2016/02/12
CRDT- 2016/02/14 06:00
PHST- 2015/04/28 00:00 [received]
PHST- 2016/02/05 00:00 [accepted]
PHST- 2016/02/14 06:00 [entrez]
PHST- 2016/02/14 06:00 [pubmed]
PHST- 2016/12/30 06:00 [medline]
PHST- 2016/02/12 00:00 [pmc-release]
AID - 10.1186/s12902-016-0089-7 [pii]
AID - 89 [pii]
AID - 10.1186/s12902-016-0089-7 [doi]
PST - epublish
SO  - BMC Endocr Disord. 2016 Feb 12;16:8. doi: 10.1186/s12902-016-0089-7.