PMID- 26872721 OWN - NLM STAT- MEDLINE DCOM- 20171011 LR - 20240109 IS - 1878-0210 (Electronic) IS - 1878-0210 (Linking) VI - 10 IP - 4 DP - 2016 Aug TI - The effect of enriched chicory inulin on liver enzymes, calcium homeostasis and hematological parameters in patients with type 2 diabetes mellitus: A randomized placebo-controlled trial. PG - 265-71 LID - S1751-9918(16)00003-6 [pii] LID - 10.1016/j.pcd.2015.10.009 [doi] AB - BACKGROUNDS AND AIMS: Type 2 diabetic mellitus (T2DM) as one of the main causes of morbidity and mortality is associated with immune system disturbances and metabolic abnormalities. In the current study we aimed to evaluate the effects of enriched chicory inulin supplementation on liver enzymes, serum calcium and phosphorous concentrations and hematological parameters in patients with T2DM. METHODS: Forty-six diabetic females patients were randomly allocated into intervention (n=27) and control (n=22) groups. Subjects in the intervention group received a daily dose of 10g of chicory and subjects in control group received a placebo for two months. Anthropometric variables, glucose homeostasis, hematological parameters and metabolic indices including serum alanine aminotransfersae (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), calcium and phosphorous as well as creatinine concentrations, glomerular filtration rate (GFR) and blood pressure were assessed at the beginning and end of the trial. RESULTS: Significant reductions in fasting serum glucose (FSG), Hb A1C, AST and ALP concentrations were observed in chicory-treated group. Systolic and diastolic blood pressures were also reduced in chicory-treated group. Serum calcium significantly increased after chicory supplementation but no change in placebo treated group has been occurred (P=0.014). Supplementation with enriched chicory for two months significantly reduced hematocrit and mean corpuscular volume (MCV) values (P<0.05). Changes in serum insulin, creatinine and GFR were not significant. CONCLUSION: The present study showed beneficial effects of oligofructose-enriched chicory on the improvement of the glucose and calcium homeostasis, liver function tests, blood pressure and reduction in hematologic risk factors of diabetes in female patients with T2DM. Further studies in both genders are needed to generalize these findings to total population. CI - Copyright (c) 2016 Primary Care Diabetes Europe. Published by Elsevier Ltd. All rights reserved. FAU - Farhangi, Mahdieh Abbasalizad AU - Farhangi MA AD - Nutrition Research Center, Department of Nutrition in Community, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: abbasalizad_m@yahoo.com. FAU - Javid, Ahmad Zare AU - Javid AZ AD - Nutrition and Metabolic Diseases Research Center, Hyperlipidemia Research Center, Ahvaz Jundishapur, University of Medical Sciences, Ahwaz, Iran. FAU - Dehghan, Parvin AU - Dehghan P AD - Nutrition Research Center, Department of Food Science and Technology, School of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: dehghan.nut@gmail.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20160210 PL - England TA - Prim Care Diabetes JT - Primary care diabetes JID - 101463825 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin A) RN - 0 (Prebiotics) RN - 0 (hemoglobin A1c protein, human) RN - 27YLU75U4W (Phosphorus) RN - 9005-80-5 (Inulin) RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - EC 2.6.1.2 (Alanine Transaminase) RN - SY7Q814VUP (Calcium) SB - IM MH - Adult MH - Alanine Transaminase/*blood MH - Aspartate Aminotransferases/*blood MH - Biomarkers/blood MH - Blood Glucose/drug effects/metabolism MH - Blood Pressure/drug effects MH - Calcium/*blood MH - Cichorium intybus/*chemistry MH - Diabetes Mellitus, Type 2/blood/diagnosis/*drug therapy MH - Double-Blind Method MH - Erythrocyte Indices MH - Female MH - Glycated Hemoglobin/metabolism MH - Hematocrit MH - Homeostasis MH - Humans MH - Inulin/adverse effects/isolation & purification/*therapeutic use MH - Iran MH - Liver/*drug effects/enzymology MH - Liver Function Tests MH - Middle Aged MH - Phosphorus/blood MH - Phytotherapy MH - Plants, Medicinal MH - Prebiotics/adverse effects MH - Time Factors MH - Treatment Outcome OTO - NOTNLM OT - Calcium homeostasis OT - Chicory OT - Hematological parameters OT - Liver enzymes OT - Type 2 diabetic mellitus EDAT- 2016/02/14 06:00 MHDA- 2017/10/12 06:00 CRDT- 2016/02/14 06:00 PHST- 2015/08/01 00:00 [received] PHST- 2015/10/30 00:00 [revised] PHST- 2015/10/31 00:00 [accepted] PHST- 2016/02/14 06:00 [entrez] PHST- 2016/02/14 06:00 [pubmed] PHST- 2017/10/12 06:00 [medline] AID - S1751-9918(16)00003-6 [pii] AID - 10.1016/j.pcd.2015.10.009 [doi] PST - ppublish SO - Prim Care Diabetes. 2016 Aug;10(4):265-71. doi: 10.1016/j.pcd.2015.10.009. Epub 2016 Feb 10.