PMID- 26873590
OWN - NLM
STAT- MEDLINE
DCOM- 20170109
LR  - 20240325
IS  - 1432-1041 (Electronic)
IS  - 0031-6970 (Print)
IS  - 0031-6970 (Linking)
VI  - 72
IP  - 5
DP  - 2016 May
TI  - Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch 
      geriatric outpatients.
PG  - 605-14
LID - 10.1007/s00228-016-2016-2 [doi]
AB  - PURPOSE: Adverse drug reactions as well as vitamin D deficiency are issues of 
      public health concern in older people. However, relatively little is known about 
      the impact of drug use on vitamin D status. Our primary aim is to explore 
      associations between drug use and vitamin D status in older people. Furthermore, 
      prevalences of drug use and vitamin D deficiency are estimated. METHODS: In a 
      population of 873 community-dwelling Dutch geriatric outpatients, we explored the 
      cross-sectional relationships of polypharmacy (>/=5 medications concomitantly 
      used), severe polypharmacy (>/=10 medications), and use of twenty-one specific drug 
      groups, with serum 25-hydroxyvitamin D (25(OH)D) by analysis of covariance. 
      RESULTS: Overall prevalence of polypharmacy was 65 %, of severe polypharmacy 22 
      %. Depending on the cut-off value, prevalence of vitamin D deficiency was 49 % 
      (<50 nmol/l) or 77 % (<75 nmol/l). Of the patients using a vitamin D supplement, 
      17 % (<50 nmol/l) or 49 % (<75 nmol/l) were still deficient. In non-users of 
      supplemental vitamin D, after adjustment for age and gender, negative 
      associations were found for severe polypharmacy, metformin, sulphonamides and 
      urea derivatives (SUDs), vitamin K antagonists, cardiac glycosides, loop 
      diuretics, potassium-sparing diuretics, ACE inhibitors, and serotonin reuptake 
      inhibitors; for non-selective monoamine reuptake inhibitors (NSMRIs) the 
      association was positive. The most extreme impacts of drug use on adjusted mean 
      25(OH)D were -19 nmol/l for SUDs and +18 nmol/l for NSMRIs. CONCLUSION: Drug use 
      should be considered a risk factor for vitamin D deficiency amongst geriatric 
      outpatients.
FAU - van Orten-Luiten, A C B
AU  - van Orten-Luiten AC
AUID- ORCID: 0000-0002-5375-4004
AD  - Division of Human Nutrition, Pharmacology and Nutrition, Wageningen University, 
      P.O. Box 8129, 6700 EV, Wageningen, The Netherlands. wout.vanorten-luiten@wur.nl.
AD  - Department of Geriatric Medicine, Gelderse Vallei Hospital, Willy Brandtlaan 10, 
      6716 RP, Ede, The Netherlands. wout.vanorten-luiten@wur.nl.
FAU - Janse, A
AU  - Janse A
AD  - Department of Geriatric Medicine, Gelderse Vallei Hospital, Willy Brandtlaan 10, 
      6716 RP, Ede, The Netherlands.
FAU - Dhonukshe-Rutten, R A M
AU  - Dhonukshe-Rutten RA
AD  - Division of Human Nutrition, Wageningen University, P.O. Box 8129, 6700 EV, 
      Wageningen, The Netherlands.
FAU - Witkamp, R F
AU  - Witkamp RF
AD  - Division of Human Nutrition, Pharmacology and Nutrition, Wageningen University, 
      P.O. Box 8129, 6700 EV, Wageningen, The Netherlands. renger.witkamp@wur.nl.
LA  - eng
PT  - Journal Article
DEP - 20160212
PL  - Germany
TA  - Eur J Clin Pharmacol
JT  - European journal of clinical pharmacology
JID - 1256165
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cross-Sectional Studies
MH  - Drug Utilization/statistics & numerical data
MH  - Drug-Related Side Effects and Adverse Reactions/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Netherlands/epidemiology
MH  - Outpatients
MH  - Polypharmacy
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/blood/*chemically induced/*epidemiology
PMC - PMC4834096
OTO - NOTNLM
OT  - Adverse drug reaction
OT  - Drug-food interaction
OT  - Elderly
OT  - Polypharmacy
OT  - Vitamin D
EDAT- 2016/02/14 06:00
MHDA- 2017/01/10 06:00
PMCR- 2016/02/12
CRDT- 2016/02/14 06:00
PHST- 2015/11/19 00:00 [received]
PHST- 2016/01/19 00:00 [accepted]
PHST- 2016/02/14 06:00 [entrez]
PHST- 2016/02/14 06:00 [pubmed]
PHST- 2017/01/10 06:00 [medline]
PHST- 2016/02/12 00:00 [pmc-release]
AID - 10.1007/s00228-016-2016-2 [pii]
AID - 2016 [pii]
AID - 10.1007/s00228-016-2016-2 [doi]
PST - ppublish
SO  - Eur J Clin Pharmacol. 2016 May;72(5):605-14. doi: 10.1007/s00228-016-2016-2. Epub 
      2016 Feb 12.