PMID- 26874209
OWN - NLM
STAT- MEDLINE
DCOM- 20170110
LR  - 20170111
IS  - 1873-3379 (Electronic)
IS  - 0891-4222 (Linking)
VI  - 53-54
DP  - 2016 Jun-Jul
TI  - A 3-year follow-up study on cardiovascular disease and mortality in older people 
      with intellectual disabilities.
PG  - 115-26
LID - S0891-4222(16)30020-8 [pii]
LID - 10.1016/j.ridd.2016.01.020 [doi]
AB  - BACKGROUND: With increasing longevity and a similar or increased prevalence of 
      cardiovascular disease risk factors (as compared to the general population), 
      people with intellectual disabilities (IDs) are at risk of developing 
      cardiovascular disease. However, prospective studies on incidence and influencing 
      factors of cardiovascular disease and mortality are lacking. METHODS: A three 
      year follow-up study was undertaken to study the incidence and symptoms at 
      presentation of myocardial accident, stroke and heart failure in older people 
      with ID. Furthermore, the predictive value of cardiovascular disease risk factors 
      on myocardial accident, stroke and heart failure and on all-cause mortality were 
      studied. The baseline group consisted of the 1050 participants, aged 50 years and 
      over, in the Dutch Healthy Ageing and Intellectual Disability (HA-ID) study. 
      Baseline measurements were conducted between November 2008 and July 2010. Three 
      years after baseline, medical files of 790 participants were studied. RESULTS: 
      Cardiovascular disease (myocardial infarction, stroke and heart failure) occurred 
      in 5.9% of the population during 3 year follow-up, and 32% of them died due to 
      the condition. Incidence of myocardial infarction is 2.8 per 1000 personyears, 
      for stroke 3.2 per 1000 personyears and for heart failure 12.5 per 1000 
      personyears. Incidence of these conditions is probably underestimated, due to 
      atypical symptom presentation. The use of atypical antipsychotics and a history 
      of heart failure were predictive for myocardial infarction. Heart failure was 
      predicted by abdominal obesity, chronic kidney disease and a history of heart 
      failure. A total of cardiovascular disease (myocardial infarction, stroke or 
      heart failure) was predicted by abdominal obesity, a history of stroke and a 
      history of heart failure. A low body-mass index, peripheral arterial disease, 
      chronic kidney disease and inflammation were predictive for 3-year all-cause 
      mortality. CONCLUSION: Incidence of cardiovascular disease in older people with 
      ID is similar to that in the general population. A pro-active assessment and 
      treatment of the presented cardiovascular disease risk factors may reduce 
      cardiovascular disease and mortality in older people with ID.
CI  - Copyright (c) 2016 Elsevier Ltd. All rights reserved.
FAU - de Winter, C F
AU  - de Winter CF
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands; Reinaerde, Den Dolder, The 
      Netherlands. Electronic address: channadewinter@hotmail.com.
FAU - van den Berge, A P J
AU  - van den Berge AP
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands.
FAU - Schoufour, J D
AU  - Schoufour JD
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands.
FAU - Oppewal, A
AU  - Oppewal A
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands.
FAU - Evenhuis, H M
AU  - Evenhuis HM
AD  - Intellectual Disability Medicine, Erasmus Medical Center Rotterdam, Department of 
      General Practice, Rotterdam, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160211
PL  - United States
TA  - Res Dev Disabil
JT  - Research in developmental disabilities
JID - 8709782
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Antipsychotic Agents/*therapeutic use
MH  - Cardiovascular Diseases/epidemiology/mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Inflammation/epidemiology
MH  - Intellectual Disability/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - Netherlands/epidemiology
MH  - Obesity, Abdominal/*epidemiology
MH  - Peripheral Arterial Disease/*epidemiology
MH  - Proportional Hazards Models
MH  - Renal Insufficiency, Chronic/*epidemiology
MH  - Risk Factors
MH  - Stroke/*epidemiology
MH  - Thinness/epidemiology
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Epidemiology
OT  - Heart failure
OT  - Intellectual disability
OT  - Myocardial infarction
OT  - Risk factors
OT  - Stroke
EDAT- 2016/02/14 06:00
MHDA- 2017/01/11 06:00
CRDT- 2016/02/14 06:00
PHST- 2015/07/23 00:00 [received]
PHST- 2016/01/21 00:00 [revised]
PHST- 2016/01/28 00:00 [accepted]
PHST- 2016/02/14 06:00 [entrez]
PHST- 2016/02/14 06:00 [pubmed]
PHST- 2017/01/11 06:00 [medline]
AID - S0891-4222(16)30020-8 [pii]
AID - 10.1016/j.ridd.2016.01.020 [doi]
PST - ppublish
SO  - Res Dev Disabil. 2016 Jun-Jul;53-54:115-26. doi: 10.1016/j.ridd.2016.01.020. Epub 
      2016 Feb 11.