PMID- 26874918
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20181202
IS  - 2210-7762 (Print)
VI  - 209
IP  - 4
DP  - 2016 Apr
TI  - Detection of an early adult T-cell leukemia-lymphoma clone in lymph nodes with 
      anaplastic lymphoma kinase-negative anaplastic large cell lymphoma involvement.
PG  - 138-42
LID - S2210-7762(16)30001-1 [pii]
LID - 10.1016/j.cancergen.2016.01.002 [doi]
AB  - A 58-year-old man was admitted to our hospital with systemic lymphadenopathy and 
      was diagnosed with anaplastic lymphoma kinase-negative anaplastic large cell 
      lymphoma (ALCL) by lymph node biopsy. Although he was a human T-cell leukemia 
      virus type I (HTLV-1) carrier, Southern blot analysis of the lymph node did not 
      show monoclonal integration of HTLV-1 provirus deoxyribonucleic acid (DNA). He 
      achieved complete remission after chemotherapy and subsequently, autologous 
      peripheral blood stem cell transplantation (auto-PBSCT) was performed. Fifteen 
      months after the auto-PBSCT, abnormal lymphocytes in the peripheral blood 
      gradually increased. Southern blot analysis revealed monoclonal integration of 
      HTLV-1 provirus DNA and monoclonal rearrangement of TRB. He was diagnosed with 
      chronic type adult T-cell leukemia-lymphoma (ATL), which immediately progressed 
      to the acute type. He died of tumor progression despite intensive chemotherapy. 
      We analyzed genomic alterations of the ALCL and ATL cells using array comparative 
      genomic hybridization. We found that the genomic alteration pattern differed 
      between the two diseases. T-cell receptor clonality analysis using polymerase 
      chain reaction (PCR) showed that the T-cell clone of the ATL was present in the 
      lymph nodes with ALCL involvement, but not in peripheral blood. This finding 
      suggests that lymph nodes can serve as a niche for ATL development.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Tokunaga, Masahito
AU  - Tokunaga M
AD  - Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan. Electronic 
      address: ma.tokunaga@jiaikai.jp.
FAU - Yoshida, Noriaki
AU  - Yoshida N
AD  - Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
FAU - Nakano, Nobuaki
AU  - Nakano N
AD  - Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
FAU - Kubota, Ayumu
AU  - Kubota A
AD  - Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
FAU - Takeuchi, Shogo
AU  - Takeuchi S
AD  - Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
FAU - Takatsuka, Yoshifusa
AU  - Takatsuka Y
AD  - Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
FAU - Seto, Masao
AU  - Seto M
AD  - Department of Pathology, Kurume University School of Medicine, Fukuoka, Japan.
FAU - Utsunomiya, Atae
AU  - Utsunomiya A
AD  - Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160127
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
RN  - EC 2.7.10.1 (ALK protein, human)
RN  - EC 2.7.10.1 (Anaplastic Lymphoma Kinase)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Anaplastic Lymphoma Kinase
MH  - Cloning, Molecular
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/*diagnosis/pathology
MH  - Lymph Nodes/*pathology
MH  - Lymphoma, Large-Cell, Anaplastic/*diagnosis/enzymology/pathology
MH  - Male
MH  - Middle Aged
MH  - Receptor Protein-Tyrosine Kinases/analysis
OTO - NOTNLM
OT  - ALK-negative anaplastic large cell lymphoma
OT  - T-cell clonality assay
OT  - adult T-cell leukemia-lymphoma
OT  - genomic alteration profiles
OT  - human T-cell leukemia virus type I
EDAT- 2016/02/15 06:00
MHDA- 2016/09/23 06:00
CRDT- 2016/02/15 06:00
PHST- 2015/07/13 00:00 [received]
PHST- 2015/11/22 00:00 [revised]
PHST- 2016/01/22 00:00 [accepted]
PHST- 2016/02/15 06:00 [entrez]
PHST- 2016/02/15 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S2210-7762(16)30001-1 [pii]
AID - 10.1016/j.cancergen.2016.01.002 [doi]
PST - ppublish
SO  - Cancer Genet. 2016 Apr;209(4):138-42. doi: 10.1016/j.cancergen.2016.01.002. Epub 
      2016 Jan 27.