PMID- 26874947
OWN - NLM
STAT- MEDLINE
DCOM- 20170411
LR  - 20201216
IS  - 1615-2573 (Electronic)
IS  - 0910-8327 (Linking)
VI  - 31
IP  - 11
DP  - 2016 Nov
TI  - Gender differences in plaque characteristics of culprit lesions in patients with 
      ST elevation myocardial infarction.
PG  - 1767-1775
AB  - There is limited research on plaque characteristics of ST elevation myocardial 
      infarction (STEMI) patients according to the gender and age. 280 Consecutive 
      STEMI patients who underwent VH-IVUS imaging on culprit before percutaneous 
      coronary intervention (PCI) were enrolled in this study. Women were significantly 
      older than men (69.8 +/- 10 vs. 55.9 +/- 11.3, p < 0.001). After propensity matching, 
      men had higher plaque burden (79.7 +/- 7.8 vs. 73.7 +/- 13.0 %, p = 0.010), more 
      fibro-fatty tissue (12.8 +/- 9.9 vs. 9.5 +/- 6.8 %, p = 0.04) and less dense calcium 
      than women (8.4 +/- 5.8 vs. 12.3 +/- 8.7 %, p = 0.007). Subgroups dividing by 50, 65, 
      75 years old, plaque burden was higher in elderly men aged 66-75 years compared 
      to the young men aged less than 50 (75.5 +/- 9.2 vs. 68.4 +/- 10.1 %, p = 0.012). And 
      middle aged men ranged 51-65 years showed significantly more plaque burden at 
      minimal lumen area site than matched aged women (77.5 +/- 8.0 vs. 69.0 +/- 17.6 %, 
      p = 0.012). Elderly women aged 66-75 years showed significantly more necrotic 
      core (28.6 +/- 7.3 %) and dense calcium (14.9 +/- 7.5 %) compared to all the younger 
      or matched subgroups of men. These differences in plaque composition are blunted 
      in the very elderly of men and women aged over 75 years. The findings may explain 
      the gender differences in clinical prognosis in STEMI patients.
FAU - Ann, Soe Hee
AU  - Ann SH
AD  - Department of Cardiology, Ulsan University Hospital, University of Ulsan College 
      of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 682-714, South Korea.
FAU - De Jin, Cai
AU  - De Jin C
AD  - Department of Cardiology, Dong-A University Hospital, Busan, South Korea.
FAU - Singh, Gillian Balbir
AU  - Singh GB
AD  - Department of Cardiology, Ulsan University Hospital, University of Ulsan College 
      of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 682-714, South Korea.
FAU - Lim, Kyung Hun
AU  - Lim KH
AD  - Department of Cardiology, Ulsan University Hospital, University of Ulsan College 
      of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 682-714, South Korea.
FAU - Chung, Jae-Wook
AU  - Chung JW
AD  - College of Medicine, Yeungnam University, Daegu, South Korea.
FAU - Garg, Scot
AU  - Garg S
AD  - East Lancashire Hospitals NHS Trust, Blackburn, Lancashire, UK.
FAU - Kim, Moo Hyun
AU  - Kim MH
AD  - Department of Cardiology, Dong-A University Hospital, Busan, South Korea.
FAU - Lee, Wang-Soo
AU  - Lee WS
AD  - Department of Cardiology, Chung-Ang University Hospital, Heukseok-dong, 
      Dongjak-gu, 156-755, Seoul, South Korea.
FAU - Cho, Kyoung Im
AU  - Cho KI
AD  - Department of Cardiology, Kosin University School of Medicine, Busan, South 
      Korea.
FAU - Kim, Sang Wook
AU  - Kim SW
AD  - Department of Cardiology, Chung-Ang University Hospital, Heukseok-dong, 
      Dongjak-gu, 156-755, Seoul, South Korea. swivus@gmail.com.
FAU - Shin, Eun-Seok
AU  - Shin ES
AD  - Department of Cardiology, Ulsan University Hospital, University of Ulsan College 
      of Medicine, 877 Bangeojinsunhwan-doro, Dong-gu, Ulsan, 682-714, South Korea. 
      sesim1989@gmail.com.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20160213
PL  - Japan
TA  - Heart Vessels
JT  - Heart and vessels
JID - 8511258
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Chi-Square Distribution
MH  - Coronary Angiography
MH  - Coronary Artery Disease/complications/diagnostic imaging/*pathology
MH  - Coronary Vessels/diagnostic imaging/*pathology
MH  - Female
MH  - Fibrosis
MH  - *Health Status Disparities
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Necrosis
MH  - *Plaque, Atherosclerotic
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Propensity Score
MH  - Registries
MH  - Risk Factors
MH  - Rupture, Spontaneous
MH  - ST Elevation Myocardial Infarction/diagnostic imaging/*etiology
MH  - Sex Factors
MH  - Ultrasonography, Interventional
MH  - Vascular Calcification/diagnostic imaging/pathology
OTO - NOTNLM
OT  - Age
OT  - Gender
OT  - ST elevation myocardial infarction
OT  - Virtual histology intravascular ultrasound
EDAT- 2016/11/01 06:00
MHDA- 2017/04/12 06:00
CRDT- 2016/02/15 06:00
PHST- 2015/07/28 00:00 [received]
PHST- 2016/01/29 00:00 [accepted]
PHST- 2016/11/01 06:00 [pubmed]
PHST- 2017/04/12 06:00 [medline]
PHST- 2016/02/15 06:00 [entrez]
AID - 10.1007/s00380-016-0806-1 [pii]
AID - 10.1007/s00380-016-0806-1 [doi]
PST - ppublish
SO  - Heart Vessels. 2016 Nov;31(11):1767-1775. doi: 10.1007/s00380-016-0806-1. Epub 
      2016 Feb 13.