PMID- 26876005 OWN - NLM STAT- MEDLINE DCOM- 20161219 LR - 20221115 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 6 DP - 2016 Feb 15 TI - Endocardial Remodeling in Heart Failure Patients with Impaired and Preserved Left Ventricular Systolic Function--A Magnetic Resonance Image Study. PG - 20868 LID - 10.1038/srep20868 [doi] LID - 20868 AB - Left ventricular (LV) trabeculation has been studied in certain forms of cardiomyopathy. However, the changes of LV endocardial trabeculation during the remodeling process leading to heart failure (HF) are unclear. Seventy-four patients with systolic heart failure (SHF), 65 with heart failure with preserved ejection fraction (HFpEF) and 61 without HF were prospectively enrolled. All subjects received magnetic resonance imaging (MRI) study including cine, T1 and late gadolinium enhancement (LGE) images. Trabecular-papillary muscle (TPM) mass, fractal dimension (FD) and extracellular volume (ECV) were derived. The results showed that TPM mass index was higher in patients with SHF than that in patients with HFpEF and non-HF. The TPM mass-LV mass ratio (TPMm/LVM) was higher in SHF group than that in HFpEF and non-HF. FD was not different among groups. The presence of LGE was inversely associated with TPM mass index and TPMm/LVM while the ECV were positively associated with TPMm/LVM. The FD was positively associated with LV chamber size. In conclusion, TPM increases in patients with SHF and are probably related to myocardial cell hypertrophy and fibrotic repair during remodeling. The FD increases with the dilatation of LV chamber but remain unchanged with the deterioration of LV function. FAU - Lin, Lian-Yu AU - Lin LY AD - Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. FAU - Su, Mao-Yuan M AU - Su MY AD - Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. FAU - Pham, Van-Truong AU - Pham VT AD - Institute of Translational and Interdisciplinary Medicine and Department of Biomedical Sciences and Engineering, National Central University, Chungli, Taiwan. FAU - Tran, Thi-Thao AU - Tran TT AD - Department of Electrical Engineering, National Central University, Chungli, Taiwan. FAU - Wang, Yung-Hung AU - Wang YH AD - Institute of Translational and Interdisciplinary Medicine and Department of Biomedical Sciences and Engineering, National Central University, Chungli, Taiwan. FAU - Tseng, Wen-Yih I AU - Tseng WY AD - Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan. AD - Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan. FAU - Lo, Men-Tzung AU - Lo MT AD - Institute of Translational and Interdisciplinary Medicine and Department of Biomedical Sciences and Engineering, National Central University, Chungli, Taiwan. FAU - Lin, Jiunn-Lee AU - Lin JL AD - Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20160215 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Contrast Media) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Aged MH - Cardiomegaly/*diagnostic imaging/metabolism/pathology/physiopathology MH - Contrast Media/metabolism MH - Female MH - Fibrosis MH - Gadolinium DTPA/metabolism MH - Heart Failure/*diagnostic imaging/metabolism/pathology/physiopathology MH - Humans MH - Image Enhancement MH - Magnetic Resonance Imaging/*methods MH - Male MH - Middle Aged MH - Myocardium/metabolism/pathology MH - Prospective Studies MH - Stroke Volume MH - Ventricular Function, Left PMC - PMC4753516 EDAT- 2016/02/16 06:00 MHDA- 2016/12/20 06:00 PMCR- 2016/02/15 CRDT- 2016/02/16 06:00 PHST- 2015/11/27 00:00 [received] PHST- 2016/01/08 00:00 [accepted] PHST- 2016/02/16 06:00 [entrez] PHST- 2016/02/16 06:00 [pubmed] PHST- 2016/12/20 06:00 [medline] PHST- 2016/02/15 00:00 [pmc-release] AID - srep20868 [pii] AID - 10.1038/srep20868 [doi] PST - epublish SO - Sci Rep. 2016 Feb 15;6:20868. doi: 10.1038/srep20868.