PMID- 26878640
OWN - NLM
STAT- MEDLINE
DCOM- 20161230
LR  - 20210109
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Print)
IS  - 0048-9697 (Linking)
VI  - 551-552
DP  - 2016 May 1
TI  - Persistent organic pollutants and pregnancy complications.
PG  - 285-91
LID - S0048-9697(16)30241-8 [pii]
LID - 10.1016/j.scitotenv.2016.02.030 [doi]
AB  - We sought to investigate the relationship between maternal preconception 
      exposures to persistent organic pollutants (POPs) and pregnancy complications, 
      gestational diabetes (GDM) and gestational hypertension. Data from 258 (51%) 
      women with human chorionic gonadotropin (hCG) confirmed pregnancies reaching 
      >/=24weeks gestation, from a prospective cohort of 501 couples who discontinued 
      contraception to attempt pregnancy, were analyzed. Preconception concentrations 
      of 9 organochlorine pesticides (OCPs) and 10 polybrominated diphenyl ethers 
      (PBDEs) were quantified in serum. In separate multiple logistic regression models 
      of self-reported physician diagnosed outcomes: GDM (11%) and gestational 
      hypertension (10%), chemicals were natural log-transformed and rescaled by their 
      standard deviation (SD). Models were adjusted for serum lipids, and then adjusted 
      for age, body mass index, race, and smoking. Models were additionally adjusted 
      for the sum of the remaining POPs in each chemical class. Women's serum 
      concentration of PBDE congener 153 (PBDE-153) was positively associated with an 
      increased odds of GDM per SD increase in log-transformed concentration, for 
      unadjusted (OR=1.36, 95%CI: 1.02-1.81), a priori adjusted (OR=1.38, 95% CI: 
      1.03-1.86) and with the sum of remaining PBDEs (OR=1.79, 95% CI: 1.18, 2.74) 
      models. Our findings suggest that at environmentally relevant concentrations, 
      maternal exposure to POPs prior to conception may contribute to increased chance 
      of developing GDM.
CI  - Published by Elsevier B.V.
FAU - Smarr, Melissa M
AU  - Smarr MM
AD  - Office of the Director, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. 
      Electronic address: melissa.smarr@mail.nih.gov.
FAU - Grantz, Katherine L
AU  - Grantz KL
AD  - Epidemiology Branch, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. 
      Electronic address: katherine.grantz@nih.gov.
FAU - Zhang, Cuilin
AU  - Zhang C
AD  - Epidemiology Branch, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. 
      Electronic address: zhangcu@mail.nih.gov.
FAU - Sundaram, Rajeshwari
AU  - Sundaram R
AD  - Biostatistics and Bioinformatics Branch, Division of Intramural Population Health 
      Research, Eunice Kennedy Shriver National Institute of Child Health and Human 
      Development, National Institutes of Health, 6100 Executive Blvd., Rockville, MD 
      20852, USA.. Electronic address: sundaramr2@mail.nih.gov.
FAU - Maisog, Jose M
AU  - Maisog JM
AD  - Glotech, Inc., Rockville, MD 20852, USA. Electronic address: bravas02@gmail.com.
FAU - Barr, Dana Boyd
AU  - Barr DB
AD  - Department of Environmental Health, Rollins School of Public Health, Emory 
      University, 1518 Clifton Rd, Atlanta, GA 30322, USA. Electronic address: 
      dbbarr@emory.edu.
FAU - Louis, Germaine M Buck
AU  - Louis GM
AD  - Office of the Director, Division of Intramural Population Health Research, Eunice 
      Kennedy Shriver National Institute of Child Health and Human Development, 
      National Institutes of Health, 6100 Executive Blvd., Rockville, MD 20852, USA.. 
      Electronic address: louisg@mail.nih.gov.
LA  - eng
GR  - Z99 HD999999/ImNIH/Intramural NIH HHS/United States
GR  - N0H-HD-3-3358/HD/NICHD NIH HHS/United States
GR  - N01-HD-3-3356/HD/NICHD NIH HHS/United States
GR  - N01-HD-3-3355/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20160212
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 0 (Polybrominated Biphenyls)
RN  - NX58WCQ511 (2,2',4,4',5,5'-hexabrominated diphenyl ether)
SB  - IM
MH  - Adult
MH  - Environmental Pollutants/*blood
MH  - Female
MH  - Halogenated Diphenyl Ethers/blood
MH  - Humans
MH  - Hydrocarbons, Chlorinated/blood
MH  - Maternal Exposure/*statistics & numerical data
MH  - Pesticides/blood
MH  - Polybrominated Biphenyls/blood
MH  - Pregnancy
MH  - Pregnancy Complications/*epidemiology
MH  - Prospective Studies
PMC - PMC7751424
MID - NIHMS760185
OTO - NOTNLM
OT  - Gestational diabetes mellitus
OT  - Hypertension
OT  - Organochlorine pesticides
OT  - Polybrominated diphenyl ethers
OT  - Preconception
EDAT- 2016/02/16 06:00
MHDA- 2016/12/31 06:00
PMCR- 2020/12/21
CRDT- 2016/02/16 06:00
PHST- 2015/12/02 00:00 [received]
PHST- 2016/01/27 00:00 [revised]
PHST- 2016/02/04 00:00 [accepted]
PHST- 2016/02/16 06:00 [entrez]
PHST- 2016/02/16 06:00 [pubmed]
PHST- 2016/12/31 06:00 [medline]
PHST- 2020/12/21 00:00 [pmc-release]
AID - S0048-9697(16)30241-8 [pii]
AID - 10.1016/j.scitotenv.2016.02.030 [doi]
PST - ppublish
SO  - Sci Total Environ. 2016 May 1;551-552:285-91. doi: 
      10.1016/j.scitotenv.2016.02.030. Epub 2016 Feb 12.