PMID- 26878954
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 5
IP  - 1
DP  - 2012 Mar
TI  - Early intervention in psychosis: Insights from Korea.
PG  - 98-105
LID - 10.1016/j.ajp.2012.02.007 [doi]
AB  - Subjects at clinical high risk (CHR) for psychosis have been the focus of 
      clinical attention in psychiatry for the last 15 years, leading to the 
      development of valid and reliable diagnostic instruments to detect these 
      individuals early in the course of their illness. These efforts have resulted in 
      research into optimal preventive measures. Our experiences at and data from the 
      Seoul Youth Clinic support the validity of the CHR concept and its underlying 
      neurobiological basis and provide valuable information related to the 
      determination of appropriate clinical interventions. The limitations of the 
      current criteria for CHR, such as the relatively low transition rates to 
      psychosis and the "false-positive" problem, are also common critical issues in 
      Korea. Additionally, concerns about social stigmatization and the potential side 
      effects of pharmacotherapy render individuals at CHR reluctant to visit clinical 
      settings. Therefore, further investigations using a combination of predictive 
      markers based on clinical and neurobiological studies of those at CHR are needed 
      to refine the diagnostic criteria, overcome their current limitations including 
      ethical issues, and develop phase-specific and individualized therapeutic 
      interventions.
CI  - Copyright A(c) 2012 Elsevier B.V. All rights reserved.
FAU - Kwon, Jun Soo
AU  - Kwon JS
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea; Department of Brain & Cognitive Sciences-WCU Program, Seoul 
      National University College of Natural Sciences, Seoul, Republic of Korea.
FAU - Byun, Min Soo
AU  - Byun MS
AD  - Department of Psychiatry, Seoul National University College of Medicine, Seoul, 
      Republic of Korea.
FAU - Lee, Tae Young
AU  - Lee TY
AD  - Department of Neuropsychiatry, Seoul National University Hospital, Seoul, 
      Republic of Korea.
FAU - An, Suk Kyoon
AU  - An SK
AD  - Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic 
      of Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120302
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
RN  - 0 (Antipsychotic Agents)
SB  - IM
MH  - Adolescent
MH  - Antipsychotic Agents/*therapeutic use
MH  - Cognitive Behavioral Therapy/*methods
MH  - Cohort Studies
MH  - Disease Progression
MH  - *Early Medical Intervention
MH  - False Positive Reactions
MH  - Female
MH  - Humans
MH  - Male
MH  - *Prodromal Symptoms
MH  - Psychotic Disorders/*therapy
MH  - Republic of Korea
MH  - Risk
MH  - Social Stigma
MH  - Young Adult
EDAT- 2012/03/01 00:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/17 06:00
PHST- 2011/12/07 00:00 [received]
PHST- 2012/02/08 00:00 [revised]
PHST- 2012/02/10 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2012/03/01 00:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1876-2018(12)00021-4 [pii]
AID - 10.1016/j.ajp.2012.02.007 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2012 Mar;5(1):98-105. doi: 10.1016/j.ajp.2012.02.007. Epub 
      2012 Mar 2.