PMID- 26880306
OWN - NLM
STAT- MEDLINE
DCOM- 20161226
LR  - 20181202
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Feb 16
TI  - Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic 
      Plasticity.
PG  - 21019
LID - 10.1038/srep21019 [doi]
LID - 21019
AB  - Transferrin receptor (TFR) is an important iron transporter regulating iron 
      homeostasis and has long been used as a marker for clathrin mediated endocytosis. 
      However, little is known about its additional function other than iron transport 
      in the development of central nervous system (CNS). Here we demonstrate that TFR 
      functions as a regulator to control AMPA receptor trafficking efficiency and 
      synaptic plasticity. The conditional knockout (KO) of TFR in neural progenitor 
      cells causes mice to develop progressive epileptic seizure, and dramatically 
      reduces basal synaptic transmission and long-term potentiation (LTP). We further 
      demonstrate that TFR KO remarkably reduces the binding efficiency of GluR2 to AP2 
      and subsequently decreases AMPA receptor endocytosis and recycling. Thus, our 
      study reveals that TFR functions as a novel regulator to control AMPA trafficking 
      efficiency and synaptic plasticity.
FAU - Liu, Ke
AU  - Liu K
AD  - West China Developmental &Stem Cell Institute, West China Second Hospital, State 
      Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan 
      University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 
      610041, China.
AD  - Shenzhen Key Laboratory for Molecular Biology of Neural Development, Laboratory 
      of Developmental and Regenerative Biology, Institute of Biomedicine 
      &Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of 
      Sciences, Shenzhen, Guangdong 518055, China.
AD  - SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East 
      Hospital, Tongji University School of Medicine &Advanced Institute of 
      Translational Medicine, Shanghai 200123, China.
AD  - ATCG Corp., BioBay, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.
FAU - Lei, Run
AU  - Lei R
AD  - West China Developmental &Stem Cell Institute, West China Second Hospital, State 
      Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan 
      University, and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 
      610041, China.
AD  - Shenzhen Key Laboratory for Molecular Biology of Neural Development, Laboratory 
      of Developmental and Regenerative Biology, Institute of Biomedicine 
      &Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of 
      Sciences, Shenzhen, Guangdong 518055, China.
AD  - SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East 
      Hospital, Tongji University School of Medicine &Advanced Institute of 
      Translational Medicine, Shanghai 200123, China.
AD  - ATCG Corp., BioBay, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.
FAU - Li, Qiong
AU  - Li Q
AD  - Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of 
      Health of China, Zhejiang Province,Key Laboratory of Neurobiology, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang 310058, China.
FAU - Wang, Xin-Xin
AU  - Wang XX
AD  - Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of 
      Health of China, Zhejiang Province,Key Laboratory of Neurobiology, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang 310058, China.
FAU - Wu, Qian
AU  - Wu Q
AD  - Department of Nutrition, School of Public Health, Zhejiang University, 866 
      Yuhangtang Road, Hangzhou 310058, China.
FAU - An, Peng
AU  - An P
AD  - Department of Nutrition, School of Public Health, Zhejiang University, 866 
      Yuhangtang Road, Hangzhou 310058, China.
FAU - Zhang, Jianchao
AU  - Zhang J
AD  - Shenzhen Key Laboratory for Molecular Biology of Neural Development, Laboratory 
      of Developmental and Regenerative Biology, Institute of Biomedicine 
      &Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of 
      Sciences, Shenzhen, Guangdong 518055, China.
FAU - Zhu, Minyan
AU  - Zhu M
AD  - SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East 
      Hospital, Tongji University School of Medicine &Advanced Institute of 
      Translational Medicine, Shanghai 200123, China.
AD  - ATCG Corp., BioBay, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.
FAU - Xu, Zhiheng
AU  - Xu Z
AD  - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics 
      and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
FAU - Hong, Yang
AU  - Hong Y
AD  - Department of Cell Biology &Physiology, University of Pittsburgh School of 
      Medicine, Pittsburgh, PA 15261, USA.
FAU - Wang, Fudi
AU  - Wang F
AD  - Department of Nutrition, School of Public Health, Zhejiang University, 866 
      Yuhangtang Road, Hangzhou 310058, China.
FAU - Shen, Ying
AU  - Shen Y
AD  - Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of 
      Health of China, Zhejiang Province,Key Laboratory of Neurobiology, Zhejiang 
      University School of Medicine, Hangzhou, Zhejiang 310058, China.
FAU - Li, Hongchang
AU  - Li H
AD  - Shenzhen Key Laboratory for Molecular Biology of Neural Development, Laboratory 
      of Developmental and Regenerative Biology, Institute of Biomedicine 
      &Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of 
      Sciences, Shenzhen, Guangdong 518055, China.
FAU - Li, Huashun
AU  - Li H
AD  - SARITEX Center for Stem Cell Engineering Translational Medicine, Shanghai East 
      Hospital, Tongji University School of Medicine &Advanced Institute of 
      Translational Medicine, Shanghai 200123, China.
AD  - ATCG Corp., BioBay, Suzhou Industrial Park, Suzhou, Jiangsu 215123, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160216
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Transferrin)
RN  - P6W5IXV8V9 (glutamate receptor ionotropic, AMPA 2)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - CA1 Region, Hippocampal/metabolism
MH  - Cell Membrane/metabolism
MH  - Gene Deletion
MH  - Gene Expression
MH  - Long-Term Potentiation
MH  - Mice
MH  - Mice, Knockout
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/metabolism
MH  - Protein Transport
MH  - Receptors, AMPA/*metabolism
MH  - Receptors, Transferrin/genetics/*metabolism
MH  - Seizures/genetics/metabolism/mortality
MH  - Synapses/metabolism
MH  - Synaptic Transmission/genetics
PMC - PMC4754636
EDAT- 2016/02/18 06:00
MHDA- 2016/12/27 06:00
PMCR- 2016/02/16
CRDT- 2016/02/17 06:00
PHST- 2015/10/21 00:00 [received]
PHST- 2016/01/14 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/27 06:00 [medline]
PHST- 2016/02/16 00:00 [pmc-release]
AID - srep21019 [pii]
AID - 10.1038/srep21019 [doi]
PST - epublish
SO  - Sci Rep. 2016 Feb 16;6:21019. doi: 10.1038/srep21019.