PMID- 26880358
OWN - NLM
STAT- MEDLINE
DCOM- 20161219
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 6
DP  - 2016 Feb 16
TI  - Individual Variations in Nucleus Accumbens Responses Associated with Major 
      Depressive Disorder Symptoms.
PG  - 21227
LID - 10.1038/srep21227 [doi]
LID - 21227
AB  - Abnormal reward-related responses in the nucleus accumbens (NAcc) have been 
      reported for major depressive disorder (MDD) patients. However, variability 
      exists in the reported results, which could be due to heterogeneity in 
      neuropathology of depression. To parse the heterogeneity of MDD we investigated 
      variation of NAcc responses to gain and loss anticipations using fMRI. We found 
      NAcc responses to monetary gain and loss were significantly variable across 
      subjects in both MDD and healthy control (HC) groups. The variations were seen as 
      a hyperactive response subtype that showed elevated activation to the 
      anticipation of both gain and loss, an intermediate response with greater 
      activation to gain than loss, and a suppressed-activity with reduced activation 
      to both gain and loss compared to a non-monetary condition. While these response 
      variability were seen in both MDD and HC subjects, specific symptoms were 
      significantly associated with the right NAcc variation in MDD. Both the hyper- 
      and suppressed-activity subtypes of MDD patients had severe suicidal ideation and 
      anhedonia symptoms. The intermediate subjects had less severity in these 
      symptoms. These results suggest that differing propensities in reward 
      responsiveness in the NAcc may affect the development of specific symptoms in 
      MDD.
FAU - Misaki, Masaya
AU  - Misaki M
AD  - Laureate Institute for Brain Research, Tulsa, OK, United States.
FAU - Suzuki, Hideo
AU  - Suzuki H
AD  - Laureate Institute for Brain Research, Tulsa, OK, United States.
FAU - Savitz, Jonathan
AU  - Savitz J
AD  - Laureate Institute for Brain Research, Tulsa, OK, United States.
AD  - Faculty of Community Medicine, University of Tulsa, Tulsa, OK, United States.
FAU - Drevets, Wayne C
AU  - Drevets WC
AD  - Laureate Institute for Brain Research, Tulsa, OK, United States.
AD  - Janssen Pharmaceuticals, LCC, of Johnson &Johnson, Inc., Titusville, NJ, USA.
FAU - Bodurka, Jerzy
AU  - Bodurka J
AD  - Laureate Institute for Brain Research, Tulsa, OK, United States.
AD  - Center for Biomedical Engineering, University of Oklahoma, Norman, OK, United 
      States.
AD  - College of Engineering, University of Oklahoma, Norman, OK, United States.
LA  - eng
GR  - R01 MH098099/MH/NIMH NIH HHS/United States
GR  - R01MH098099/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20160216
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Depressive Disorder, Major/*diagnosis/*physiopathology
MH  - Female
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Nucleus Accumbens/*physiopathology
MH  - Young Adult
PMC - PMC4754797
COIS- Wayne Drevets, M.D. is an employee of Johnson & Johnson, Inc., Jonathan Savitz, 
      Ph.D. has received research funding from Janssen Pharmaceuticals for an 
      independent study. Other authors have no financial interests to report.
EDAT- 2016/02/18 06:00
MHDA- 2016/12/20 06:00
PMCR- 2016/02/16
CRDT- 2016/02/17 06:00
PHST- 2015/11/11 00:00 [received]
PHST- 2016/01/18 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/20 06:00 [medline]
PHST- 2016/02/16 00:00 [pmc-release]
AID - srep21227 [pii]
AID - 10.1038/srep21227 [doi]
PST - epublish
SO  - Sci Rep. 2016 Feb 16;6:21227. doi: 10.1038/srep21227.