PMID- 26880399
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181202
IS  - 1365-2702 (Electronic)
IS  - 0962-1067 (Linking)
VI  - 25
IP  - 7-8
DP  - 2016 Apr
TI  - The use of nonsteroidal anti-inflammatory drugs and analgesics by liver 
      transplant recipients.
PG  - 1001-5
LID - 10.1111/jocn.13112 [doi]
AB  - AIMS AND OBJECTIVES: This study aimed to assess the reasons and the frequency of 
      the use of over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) 
      or analgesics by liver transplant recipients (LTR). Patient awareness of possible 
      drug-related side-effects was also assessed. BACKGROUND: NSAIDs and analgesics 
      available without prescription belong to the most commonly used class of drugs. 
      However, use of these drugs might be complicated by toxic adverse effects (AEs). 
      Patients at risk for AEs include the transplant recipients. DESIGN/METHODS: This 
      was a descriptive study. An anonymous survey was carried out in 73 randomly 
      selected LTR, who represented 10% of all LTR at our centre. RESULTS: There were 
      64% of the patients who confirmed taking NSAIDs or analgesics; 16% of these 
      patients took these drugs at least several times a week and 10% took them daily. 
      For 39% of patients, the only way to manage their pain were OTC NSAIDs or 
      analgesics. As many as 36% of patients were unaware of the risks associated with 
      the use of these drugs. Ninety per cent of LTR consider physicians the most 
      trusted source of drugs information. CONCLUSIONS: Our study shows that two-thirds 
      of LTR take OTC NSAIDs or analgesics and one-third are unaware of the AEs 
      associated with these drugs. Therefore, both transplant nurses and doctors should 
      educate their patients about the use and possible AE of these drugs. RELEVANCE TO 
      CLINICAL PRACTICE: Considering the high NSAIDs consumption rates, the side 
      effects of these drugs should always be suspected. Especially in patients taking 
      these drugs and referring to medical advisors with specific symptoms, such as: 
      abdominal pain, anaemia, elevated serum creatinine concentration or liver enzymes 
      activity. Awareness of the scale of the problem enables health professionals to 
      cooperate in educating patients. Such practices may reduce uncontrolled abuse of 
      these drugs and related health care costs.
CI  - (c) 2016 John Wiley & Sons Ltd.
FAU - Mulka-Gierek, Maria
AU  - Mulka-Gierek M
AD  - Department of Immunology, Transplantology and Internal Diseases, Medical 
      University of Warsaw, Warsaw, Poland.
FAU - Foroncewicz, Bartosz
AU  - Foroncewicz B
AD  - Department of Immunology, Transplantology and Internal Diseases, Medical 
      University of Warsaw, Warsaw, Poland.
FAU - Florczak, Michal
AU  - Florczak M
AD  - Department of Immunology, Transplantology and Internal Diseases, Medical 
      University of Warsaw, Warsaw, Poland.
FAU - Paczek, Leszek
AU  - Paczek L
AD  - Department of Immunology, Transplantology and Internal Diseases, Medical 
      University of Warsaw, Warsaw, Poland.
FAU - Krawczyk, Marek
AU  - Krawczyk M
AD  - Department of General, Liver and Transplant Surgery, Medical University of 
      Warsaw, Warsaw, Poland.
FAU - Mucha, Krzysztof
AU  - Mucha K
AD  - Department of Immunology, Transplantology and Internal Diseases, Medical 
      University of Warsaw, Warsaw, Poland.
AD  - Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, 
      Poland.
LA  - eng
PT  - Journal Article
DEP - 20160216
PL  - England
TA  - J Clin Nurs
JT  - Journal of clinical nursing
JID - 9207302
RN  - 0 (Analgesics)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Nonprescription Drugs)
MH  - Adult
MH  - Aged
MH  - Analgesics/*therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Cohort Studies
MH  - End Stage Liver Disease/complications/surgery
MH  - Female
MH  - Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - *Liver Transplantation
MH  - Male
MH  - Middle Aged
MH  - Nonprescription Drugs/*therapeutic use
MH  - Pain/*drug therapy
MH  - Surveys and Questionnaires
MH  - Young Adult
OTO - NOTNLM
OT  - NSAID
OT  - OTC
OT  - analgesics
OT  - awareness
OT  - liver transplantation
OT  - survey
EDAT- 2016/02/18 06:00
MHDA- 2016/12/15 06:00
CRDT- 2016/02/17 06:00
PHST- 2015/09/27 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1111/jocn.13112 [doi]
PST - ppublish
SO  - J Clin Nurs. 2016 Apr;25(7-8):1001-5. doi: 10.1111/jocn.13112. Epub 2016 Feb 16.