PMID- 26880943
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20160216
LR  - 20210105
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2016
DP  - 2016
TI  - The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into 
      Vascular Endothelial-Like Cells.
PG  - 2539781
LID - 10.1155/2016/2539781 [doi]
LID - 2539781
AB  - Bone marrow stromal cells (BMSCs) can differentiate into vascular endothelial 
      cells (VECs). It is regarded as an important solution to cure many diseases, such 
      as ischemic diseases and diabetes. However, the mechanisms underlying BMSC 
      differentiation into VECs are not well understood. Recent reports showed that 
      CD163 expression was associated with angiogenesis. In this study, overexpression 
      of CD163 in BMSCs elevated the protein level of the endothelial-associated 
      markers CD31, Flk-1, eNOS, and VE-cadherin, significantly increased the 
      proportion of Alexa Fluor 488-acetylated-LDL-positive VECs, and promoted 
      angiogenesis on Matrigel. Furthermore, we demonstrated that CD163 acted 
      downstream homeobox containing 1 (Hmbox1) and upstream fibroblast growth factor 2 
      (FGF-2). These data suggested that CD163 was involved in Hmbox1/CD163/FGF-2 
      signal pathway in BMSC differentiation into vascular endothelial-like cells. We 
      found a new signal pathway and a novel target for further investigating the gene 
      control of BMSC differentiation into a VEC lineage.
FAU - Lu, Wei
AU  - Lu W
AD  - Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, 
      School of Life Science, Shandong University, Jinan 250100, China.
FAU - Su, Le
AU  - Su L
AD  - Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, 
      School of Life Science, Shandong University, Jinan 250100, China.
FAU - Yu, Zhezheng
AU  - Yu Z
AD  - Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, 
      School of Life Science, Shandong University, Jinan 250100, China.
FAU - Zhang, Shangli
AU  - Zhang S
AD  - Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, 
      School of Life Science, Shandong University, Jinan 250100, China.
FAU - Miao, Junying
AU  - Miao J
AD  - Shandong Provincial Key Laboratory of Animal Cells and Developmental Biology, 
      School of Life Science, Shandong University, Jinan 250100, China; The Key 
      Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry 
      of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, 
      Jinan 250012, China.
LA  - eng
PT  - Journal Article
DEP - 20160106
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
PMC - PMC4736601
EDAT- 2016/02/18 06:00
MHDA- 2016/02/18 06:01
PMCR- 2016/01/06
CRDT- 2016/02/17 06:00
PHST- 2015/08/15 00:00 [received]
PHST- 2015/10/29 00:00 [revised]
PHST- 2015/11/03 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/02/18 06:01 [medline]
PHST- 2016/01/06 00:00 [pmc-release]
AID - 10.1155/2016/2539781 [doi]
PST - ppublish
SO  - Stem Cells Int. 2016;2016:2539781. doi: 10.1155/2016/2539781. Epub 2016 Jan 6.