PMID- 26881108
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20181113
IS  - 1687-5443 (Electronic)
IS  - 2090-5904 (Print)
IS  - 1687-5443 (Linking)
VI  - 2016
DP  - 2016
TI  - Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal 
      Neurons.
PG  - 4145708
LID - 10.1155/2016/4145708 [doi]
LID - 4145708
AB  - The neurotrophin brain derived neurotrophic factor (BDNF) is an important growth 
      factor in the CNS. Deficits in transport of this secretory protein could underlie 
      neurodegenerative diseases. Investigation of disease-related changes in BDNF 
      transport might provide insights into the cellular mechanism underlying, for 
      example, Alzheimer's disease (AD). To analyze the role of BDNF transport in AD, 
      live cell imaging of fluorescently labeled BDNF was performed in hippocampal 
      neurons of different AD model systems. BDNF and APP colocalized with low 
      incidence in vesicular structures. Anterograde as well as retrograde transport of 
      BDNF vesicles was reduced and these effects were mediated by factors released 
      from hippocampal neurons into the extracellular medium. Transport of BDNF was 
      altered at a very early time point after onset of human APP expression or after 
      acute amyloid-beta(1-42) treatment, while the activity-dependent release of BDNF 
      remained unaffected. Taken together, extracellular cleavage products of APP 
      induced rapid changes in anterograde and retrograde transport of BDNF-containing 
      vesicles while release of BDNF was unaffected by transgenic expression of mutated 
      APP. These early transport deficits might lead to permanently impaired brain 
      functions in the adult brain.
FAU - Seifert, Bianca
AU  - Seifert B
AD  - Institute of Physiology, Medical Faculty, Otto-von-Guericke-University, 39120 
      Magdeburg, Germany.
FAU - Eckenstaler, Robert
AU  - Eckenstaler R
AD  - Institute of Physiology, Medical Faculty, Otto-von-Guericke-University, 39120 
      Magdeburg, Germany.
FAU - Ronicke, Raik
AU  - Ronicke R
AD  - Institute of Clinical Chemistry and Pathobiochemistry, Medical Faculty, 
      Otto-von-Guericke-University, 39120 Magdeburg, Germany; German Center for 
      Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
FAU - Leschik, Julia
AU  - Leschik J
AD  - Institute of Physiological Chemistry, University Medical Center of the Johannes 
      Gutenberg University, 55128 Mainz, Germany.
FAU - Lutz, Beat
AU  - Lutz B
AD  - Institute of Physiological Chemistry, University Medical Center of the Johannes 
      Gutenberg University, 55128 Mainz, Germany.
FAU - Reymann, Klaus
AU  - Reymann K
AD  - German Center for Neurodegenerative Diseases (DZNE), 39120 Magdeburg, Germany.
FAU - Lessmann, Volkmar
AU  - Lessmann V
AD  - Institute of Physiology, Medical Faculty, Otto-von-Guericke-University, 39120 
      Magdeburg, Germany; Center of Behavioral Brain Sciences (CBBS), 39106 Magdeburg, 
      Germany.
FAU - Brigadski, Tanja
AU  - Brigadski T
AD  - Institute of Physiology, Medical Faculty, Otto-von-Guericke-University, 39120 
      Magdeburg, Germany; Center of Behavioral Brain Sciences (CBBS), 39106 Magdeburg, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160110
PL  - United States
TA  - Neural Plast
JT  - Neural plasticity
JID - 100883417
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Peptide Fragments)
RN  - 0 (amyloid beta-protein (1-42))
SB  - IM
MH  - Amyloid beta-Peptides/*toxicity
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cells, Cultured
MH  - Hippocampus/drug effects/*metabolism
MH  - Humans
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Neurons/drug effects/*metabolism
MH  - Peptide Fragments/*toxicity
MH  - Protein Transport/drug effects/physiology
MH  - Transport Vesicles/drug effects/*metabolism
PMC - PMC4736975
EDAT- 2016/02/18 06:00
MHDA- 2016/12/15 06:00
PMCR- 2016/01/10
CRDT- 2016/02/17 06:00
PHST- 2015/09/18 00:00 [received]
PHST- 2015/11/26 00:00 [revised]
PHST- 2015/11/29 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
PHST- 2016/01/10 00:00 [pmc-release]
AID - 10.1155/2016/4145708 [doi]
PST - ppublish
SO  - Neural Plast. 2016;2016:4145708. doi: 10.1155/2016/4145708. Epub 2016 Jan 10.