PMID- 26881109 OWN - NLM STAT- MEDLINE DCOM- 20161109 LR - 20181113 IS - 1687-5443 (Electronic) IS - 2090-5904 (Print) IS - 1687-5443 (Linking) VI - 2016 DP - 2016 TI - N100 Repetition Suppression Indexes Neuroplastic Defects in Clinical High Risk and Psychotic Youth. PG - 4209831 LID - 10.1155/2016/4209831 [doi] LID - 4209831 AB - Highly penetrant mutations leading to schizophrenia are enriched for genes coding for N-methyl-D-aspartate receptor signaling complex (NMDAR-SC), implicating plasticity defects in the disease's pathogenesis. The importance of plasticity in neurodevelopment implies a role for therapies that target these mechanisms in early life to prevent schizophrenia. Testing such therapies requires noninvasive methods that can assess engagement of target mechanisms. The auditory N100 is an obligatory cortical response whose amplitude decreases with tone repetition. This adaptation may index the health of plasticity mechanisms required for normal development. We exposed participants aged 5 to 17 years with psychosis (n = 22), at clinical high risk (CHR) for psychosis (n = 29), and healthy controls (n = 17) to an auditory tone repeated 450 times and measured N100 adaptation (mean amplitude during first 150 tones - mean amplitude during last 150 tones). N100 adaptation was reduced in CHR and psychosis, particularly among participants <13 years old. Initial N100 blunting partially accounted for differences. Decreased change in the N100 amplitude with tone repetition may be a useful marker of defects in neuroplastic mechanisms measurable early in life. FAU - Gonzalez-Heydrich, Joseph AU - Gonzalez-Heydrich J AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA. FAU - Enlow, Michelle Bosquet AU - Enlow MB AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA. FAU - D'Angelo, Eugene AU - D'Angelo E AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA. FAU - Seidman, Larry J AU - Seidman LJ AD - Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA; Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA; Department of Psychiatry, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA. FAU - Gumlak, Sarah AU - Gumlak S AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Kim, April AU - Kim A AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Woodberry, Kristen A AU - Woodberry KA AD - Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA; Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA. FAU - Rober, Ashley AU - Rober A AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Tembulkar, Sahil AU - Tembulkar S AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - O'Donnell, Kyle AU - O'Donnell K AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Hamoda, Hesham M AU - Hamoda HM AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA. FAU - Kimball, Kara AU - Kimball K AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA. FAU - Rotenberg, Alexander AU - Rotenberg A AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. FAU - Oberman, Lindsay M AU - Oberman LM AD - Neuroplasticity and Autism Spectrum Disorder Program and Department of Psychiatry and Human Behavior, E.P. Bradley Hospital and Warren Alpert Medical School, Brown University, 1011 Veterans Memorial Parkway, East Providence, RI 02915, USA. FAU - Pascual-Leone, Alvaro AU - Pascual-Leone A AD - Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. FAU - Keshavan, Matcheri S AU - Keshavan MS AD - Department of Psychiatry, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA; Department of Psychiatry, Commonwealth Research Center, Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, USA. FAU - Duffy, Frank H AU - Duffy FH AD - Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA; Department of Neurology, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. LA - eng GR - K23 MH102358/MH/NIMH NIH HHS/United States GR - R01 MH100186/MH/NIMH NIH HHS/United States GR - 1R01MH100186/MH/NIMH NIH HHS/United States GR - U01 MH08198-06A1/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20160112 PL - United States TA - Neural Plast JT - Neural plasticity JID - 100883417 RN - 0 (Biomarkers) SB - IM MH - Acoustic Stimulation MH - *Adaptation, Physiological MH - Adolescent MH - Biomarkers MH - Cerebral Cortex/*physiopathology MH - Electroencephalography MH - Evoked Potentials MH - *Evoked Potentials, Auditory MH - Female MH - Humans MH - Male MH - *Neuronal Plasticity MH - Schizophrenia/diagnosis/*physiopathology PMC - PMC4737454 EDAT- 2016/02/18 06:00 MHDA- 2016/11/10 06:00 PMCR- 2016/01/12 CRDT- 2016/02/17 06:00 PHST- 2015/07/24 00:00 [received] PHST- 2015/09/21 00:00 [revised] PHST- 2015/10/01 00:00 [accepted] PHST- 2016/02/17 06:00 [entrez] PHST- 2016/02/18 06:00 [pubmed] PHST- 2016/11/10 06:00 [medline] PHST- 2016/01/12 00:00 [pmc-release] AID - 10.1155/2016/4209831 [doi] PST - ppublish SO - Neural Plast. 2016;2016:4209831. doi: 10.1155/2016/4209831. Epub 2016 Jan 12.