PMID- 26881255
OWN - NLM
STAT- MEDLINE
DCOM- 20161220
LR  - 20220408
IS  - 2314-6753 (Electronic)
IS  - 2314-6745 (Print)
VI  - 2016
DP  - 2016
TI  - The Expression of miR-192 and Its Significance in Diabetic Nephropathy Patients 
      with Different Urine Albumin Creatinine Ratio.
PG  - 6789402
LID - 10.1155/2016/6789402 [doi]
LID - 6789402
AB  - OBJECTIVE: To investigate the expression of miR-192 and its significance in 
      diabetic nephropathy (DN) patients. METHODS: 464 patients with type 2 diabetes 
      mellitus (T2DM) were divided into normal albuminuria group (NA, n = 157), 
      microalbuminuria group (MA, n = 159), and large amount of albuminuria group (LA, 
      n = 148). 127 healthy persons were selected as the control group (NC, n = 127). 
      The serum miR-192 levels were detected by Real-Time PCR and transforming growth 
      factor-beta1 (TGF-beta1) and fibronectin (FN) were detected by enzyme-linked 
      immunosorbent assay. The relationships among these parameters were analyzed by 
      Pearson correlation analysis and multiple linear regression analysis. RESULTS: 
      The miR-192 in the LA group was significantly lower than other groups, which was 
      lower in the MA group than in the NA group (P < 0.01). The TGF-beta1 and FN in the 
      LA group were significantly higher than other groups, which were higher in the MA 
      group than in the NA group (P < 0.01). The expression of miR-192 was negatively 
      correlated with TGF-beta1, FN, and Ln (UACR) and miR-192, TGF-beta1, and FN were 
      independent relevant factors affecting Ln (UACR) in T2DM (P < 0.01). CONCLUSIONS: 
      These findings indicate that the levels of miR-192 were lower accompanied by the 
      decrease of urine albumin creatinine ratio (UACR) and the association between 
      miR-192 and nephritic fibrosis in DN.
FAU - Ma, Xiaoyu
AU  - Ma X
AD  - Geriatrics Department, The First Hospital of China Medical University, Shenyang, 
      Liaoning, China.
FAU - Lu, Canlu
AU  - Lu C
AD  - Endocrine Department, The First Hospital of China Medical University, Shenyang, 
      Liaoning, China.
FAU - Lv, Chuan
AU  - Lv C
AD  - Endocrine Department, The People Hospital of Liaoning Province, Shenyang, 
      Liaoning, China.
FAU - Wu, Can
AU  - Wu C
AD  - Endocrine Department, The First Hospital of China Medical University, Shenyang, 
      Liaoning, China.
FAU - Wang, Qiuyue
AU  - Wang Q
AD  - Endocrine Department, The First Hospital of China Medical University, Shenyang, 
      Liaoning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160105
PL  - England
TA  - J Diabetes Res
JT  - Journal of diabetes research
JID - 101605237
RN  - 0 (FN1 protein, human)
RN  - 0 (Fibronectins)
RN  - 0 (MIRN192 microRNA, human)
RN  - 0 (MicroRNAs)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Transforming Growth Factor beta1)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Aged
MH  - Albuminuria/*metabolism
MH  - Creatinine/*urine
MH  - Diabetes Mellitus, Type 2/urine
MH  - Diabetic Nephropathies/*metabolism/urine
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fibronectins/metabolism
MH  - Fibrosis/pathology
MH  - *Gene Expression Regulation
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - MicroRNAs/*metabolism
MH  - Middle Aged
MH  - Nephritis/urine
MH  - Real-Time Polymerase Chain Reaction
MH  - Regression Analysis
MH  - Transforming Growth Factor beta1/metabolism
PMC - PMC4736386
EDAT- 2016/02/18 06:00
MHDA- 2016/12/21 06:00
PMCR- 2016/01/05
CRDT- 2016/02/17 06:00
PHST- 2015/09/11 00:00 [received]
PHST- 2015/11/28 00:00 [revised]
PHST- 2015/11/30 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/12/21 06:00 [medline]
PHST- 2016/01/05 00:00 [pmc-release]
AID - 10.1155/2016/6789402 [doi]
PST - ppublish
SO  - J Diabetes Res. 2016;2016:6789402. doi: 10.1155/2016/6789402. Epub 2016 Jan 5.