PMID- 26881697
OWN - NLM
STAT- MEDLINE
DCOM- 20160803
LR  - 20160321
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1363
DP  - 2016 Jan
TI  - Dietary restrictions, bone density, and bone quality.
PG  - 26-39
LID - 10.1111/nyas.13004 [doi]
AB  - Caloric restriction (CR), protein restriction (PR), and specific amino acid 
      restriction (e.g., methionine restriction (MR)) are different dietary 
      interventions that have been confirmed with regard to their comprehensive 
      benefits to metabolism and health. Based on bone densitometric measurements, 
      weight loss induced by dietary restriction is known to be accompanied by reduced 
      areal bone mineral density, bone mass, and/or bone size, and it is considered 
      harmful to bone health. However, because of technological advancements in bone 
      densitometric instruments (e.g., high-resolution X-ray tomography), dietary 
      restrictions have been found to cause a reduction in bone mass/size rather than 
      volumetric bone mineral density. Furthermore, when considering bone quality, bone 
      health consists of diverse indices that cannot be fully represented by 
      densitometric measurements alone. Indeed, there is evidence that moderate dietary 
      restrictions do not impair intrinsic bone material properties, despite the 
      reduction in whole-bone strength because of a smaller bone size. In the present 
      review, we integrate research evidence from traditional densitometric 
      measurements, metabolic status assays (e.g., energy metabolism, oxidative 
      stresses, and inflammatory responses), and biomaterial analyses to provide 
      revised conclusions regarding the effects of CR, PR, and MR on the skeleton.
CI  - (c) 2016 New York Academy of Sciences.
FAU - Huang, Tsang-hai
AU  - Huang TH
AD  - Laboratory of Exercise, Nutrition and Bone Biology, Institute of Physical 
      Education, Health and Leisure Studies, National Cheng Kung University, Tainan, 
      Taiwan.
FAU - Ables, Gene P
AU  - Ables GP
AD  - Orentreich Foundation for the Advancement of Science, Cold Spring-on-Hudson, New 
      York.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20160216
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Aging
MH  - Animals
MH  - Biomechanical Phenomena
MH  - *Bone Density
MH  - Bone and Bones/*physiology
MH  - *Caloric Restriction
MH  - Densitometry
MH  - *Diet
MH  - Energy Metabolism
MH  - Humans
OTO - NOTNLM
OT  - aging
OT  - caloric restriction
OT  - metabolism
OT  - methionine restriction
OT  - protein restriction
EDAT- 2016/02/18 06:00
MHDA- 2016/08/04 06:00
CRDT- 2016/02/17 06:00
PHST- 2015/07/31 00:00 [received]
PHST- 2015/12/08 00:00 [revised]
PHST- 2015/12/16 00:00 [accepted]
PHST- 2016/02/17 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/08/04 06:00 [medline]
AID - 10.1111/nyas.13004 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2016 Jan;1363:26-39. doi: 10.1111/nyas.13004. Epub 2016 Feb 16.