PMID- 2688231
OWN - NLM
STAT- MEDLINE
DCOM- 19900116
LR  - 20131121
IS  - 0041-5782 (Print)
IS  - 0041-5782 (Linking)
VI  - 151
IP  - 46
DP  - 1989 Nov 13
TI  - [Steroid response after long-term treatment with oral N-acetylcysteine in 
      patients with chronic obstructive bronchitis].
PG  - 2076-8
AB  - The significance of long-term treatment with N-acetylcystein (NAC) for the 
      steroid response on pulmonary function and general symptoms was investigated in 
      patients with chronic bronchitis and moderate respiratory obstruction. All of the 
      patients had received preliminary treatment with oral NAC in a dosage of 1,200 mg 
      daily (Mucomyst Retard) or a placebo for 22 weeks in a double-blind design. After 
      the conclusion of the long-term treatment but before the code was revealed, 37 
      non-allergic patients with irreversible respiratory obstruction participated in a 
      follow-up investigation with 30 mg prednisone daily for 14 days. The peak flow 
      was measured twice daily and the symptoms of bronchitis were registered by 
      completion of 13 visual analogue scales. Pulmonary function was measured by means 
      of spirometry on days 0, 7 and 14, respectively. In both of the treated groups, 
      slight increase in the daily registered peak flow was found but no changes in the 
      results of spirometry or the symptoms. Comparison between the groups revealed a 
      significantly greater increase in the evening peak flow in the group which had 
      received preliminary treatment with NAC. It is concluded that, in this 
      investigation, no clinically relevant effect of long-term preliminary treatment 
      with NAC on the results of a steroid test was observed in patients with chronic 
      bronchitis and moderate respiratory obstruction.
FAU - Evald, T
AU  - Evald T
FAU - Hansen, M
AU  - Hansen M
FAU - Balslov, S
AU  - Balslov S
FAU - Brorson-Riis, L
AU  - Brorson-Riis L
FAU - Hansen, N C
AU  - Hansen NC
FAU - Maltbaek, N
AU  - Maltbaek N
FAU - Thorshauge, H
AU  - Thorshauge H
LA  - dan
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
TT  - Steroidrespons efter langtidsbehandling med oral N-acetylcystein hos patienter 
      med kronisk obstruktiv bronchitis.
PL  - Denmark
TA  - Ugeskr Laeger
JT  - Ugeskrift for laeger
JID - 0141730
RN  - VB0R961HZT (Prednisone)
RN  - WYQ7N0BPYC (Acetylcysteine)
SB  - IM
MH  - Acetylcysteine/*administration & dosage
MH  - Administration, Oral
MH  - Bronchitis/*drug therapy/physiopathology
MH  - Clinical Trials as Topic
MH  - Double-Blind Method
MH  - Humans
MH  - Lung Diseases, Obstructive/*drug therapy/physiopathology
MH  - Middle Aged
MH  - Prednisone/therapeutic use
EDAT- 1989/11/13 00:00
MHDA- 1989/11/13 00:01
CRDT- 1989/11/13 00:00
PHST- 1989/11/13 00:00 [pubmed]
PHST- 1989/11/13 00:01 [medline]
PHST- 1989/11/13 00:00 [entrez]
PST - ppublish
SO  - Ugeskr Laeger. 1989 Nov 13;151(46):2076-8.