PMID- 26883452
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20160418
IS  - 2210-7762 (Print)
VI  - 209
IP  - 4
DP  - 2016 Apr
TI  - A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient.
PG  - 166-70
LID - S2210-7762(16)00014-4 [pii]
LID - 10.1016/j.cancergen.2016.01.001 [doi]
AB  - Translocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell 
      acute leukemia. In most cases, this alteration appears as the only abnormality or 
      as part of a simple karyotype. In this report, we present the first case of T 
      acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced 
      translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with 
      multiple chromosome abnormalities, most of them not previously described in the 
      literature. FISH (fluorescence in situ hybridization) and spectral karyotype 
      (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 
      16-year-old male, showed poor response to treatment and short survival (11 
      months). A detailed review of previously reported cases with t(4;11)(q21;p15) is 
      also provided. The description of this type of alterations may contribute to the 
      identification of new molecular mechanism associated to neoplastic development.
CI  - Copyright (c) 2016 Elsevier Inc. All rights reserved.
FAU - Colli, Sandra
AU  - Colli S
AD  - Laboratorio de Genetica de Neoplasias Linfoides, Instituto de Medicina 
      Experimental, CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina.
FAU - Furforo, Lilian
AU  - Furforo L
AD  - Centro Nacional de Genetica Medica, Buenos Aires, Argentina.
FAU - Rojo Pisarello, Eduardo
AU  - Rojo Pisarello E
AD  - Hospital de Alta Complejidad "Presidente Juan Domingo Peron", Formosa, Argentina.
FAU - Maidana, Marcela
AU  - Maidana M
AD  - Hospital de Alta Complejidad "Presidente Juan Domingo Peron", Formosa, Argentina.
FAU - Martin, Carlos
AU  - Martin C
AD  - Consultorio de Hematopatologia, La Plata, Argentina.
FAU - Bordone, Javier
AU  - Bordone J
AD  - Hospital de Alta Complejidad "Presidente Juan Domingo Peron", Formosa, Argentina.
FAU - Slavutsky, Irma
AU  - Slavutsky I
AD  - Laboratorio de Genetica de Neoplasias Linfoides, Instituto de Medicina 
      Experimental, CONICET-Academia Nacional de Medicina, Buenos Aires, Argentina. 
      Electronic address: islavutsky@hematologia.anm.edu.ar.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160112
PL  - United States
TA  - Cancer Genet
JT  - Cancer genetics
JID - 101539150
SB  - IM
MH  - Adolescent
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 4
MH  - Cytogenetics/methods
MH  - Humans
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - *Translocation, Genetic
OTO - NOTNLM
OT  - FISH
OT  - T-cell acute leukemia/lymphoma
OT  - cytogenetics
OT  - spectral karyotype
EDAT- 2016/02/18 06:00
MHDA- 2016/09/23 06:00
CRDT- 2016/02/18 06:00
PHST- 2015/09/21 00:00 [received]
PHST- 2015/12/02 00:00 [revised]
PHST- 2016/01/06 00:00 [accepted]
PHST- 2016/02/18 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S2210-7762(16)00014-4 [pii]
AID - 10.1016/j.cancergen.2016.01.001 [doi]
PST - ppublish
SO  - Cancer Genet. 2016 Apr;209(4):166-70. doi: 10.1016/j.cancergen.2016.01.001. Epub 
      2016 Jan 12.