PMID- 26884286
OWN - NLM
STAT- MEDLINE
DCOM- 20170407
LR  - 20170407
IS  - 2299-8306 (Electronic)
IS  - 0423-104X (Linking)
VI  - 67
IP  - 3
DP  - 2016
TI  - Fibroblast growth factor 21 and its relationship with insulin sensitivity in 
      first-degree relatives of patients with type 2 diabetes mellitus.
PG  - 260-4
LID - 10.5603/EP.a2016.0016 [doi]
AB  - INTRODUCTION: Fibroblast growth factor 21 (FGF 21) has been suggested as a 
      predictor for the development of type 2 diabetes mellitus (T2DM). MATERIAL AND 
      METHODS: We aimed to determine FGF 21 levels in normoglycaemic (Group 1) and 
      prediabetic (Group 2) first-degree relatives (FDR) of patients with T2DM in 
      comparison with normoglycaemic subjects without a history of T2DM in their FDR 
      (Group 3). RESULTS: There was a significant difference between Group 1, 2, and 3 
      with respect to plasma FGF 21 concentrations (143.3 +/- 93.8, 221.9 +/- +/- 171.7 and 
      121.2 +/- 119.8 pg/mL, respectively, p = 0.01). FGF 21 levels were significantly 
      increased in prediabetic FDR of patients with T2DM compared to normoglycaemic 
      subjects without a history of T2DM in their FDR (p = 0.02). FGF 21 levels did not 
      differ between normoglycaemic FDR of patients with T2DM and normoglycaemic 
      subjects without a history of T2DM in their FDR (p > 0.05). In the whole group, 
      FGF 21 correlated positively with age (r = 0.31, p = 0.003), BMI (r = 0.38, p < 
      0.001), systolic blood pressure (r = 0.38, p = 0.001), diastolic blood pressure 
      (r = 0.26, p = 0.02), fasting blood glucose (r = 0.24, p = 0.02), HOMA-IR (r = 
      0.23, p = 0.03), AUC glucose (r = 0.35, p = 0.001), and AUC insulin (r = 0.32, p 
      = 0.003) and negatively with HDL cholesterol (r = -0.24, p = 0.02) and Matsuda 
      ISI (r = -0.33, p = 0.002). In the regression analysis, BMI was the most 
      predictive factor for FGF 21 levels (beta = 0.41, r2 = 0.17, p < 0.001). 
      CONCLUSIONS: We showed that FGF 21 concentrations are increased in prediabetic 
      FDR of patients with T2DM and that there is a significant association between FGF 
      21 and obesity and insulin sensitivity. (Endokrynol Pol 2016; 67 (3): 260-264).
FAU - Ors, Damla
AU  - Ors D
FAU - Eroglu Altinova, Alev
AU  - Eroglu Altinova A
FAU - Yalcin, Mehmet Muhittin
AU  - Yalcin MM
AD  - Gazi University Faculty of Medicine Department of Endocrinology and Metabolism. 
      yalcin.muhittin@gmail.com.
FAU - Gulbahar, Ozlem
AU  - Gulbahar O
FAU - Akturk, Mujde
AU  - Akturk M
FAU - Arslan, Metin
AU  - Arslan M
FAU - Balos Toruner, Fusun
AU  - Balos Toruner F
LA  - eng
PT  - Journal Article
DEP - 20160217
PL  - Poland
TA  - Endokrynol Pol
JT  - Endokrynologia Polska
JID - 0370674
RN  - 0 (fibroblast growth factor 21)
RN  - 62031-54-3 (Fibroblast Growth Factors)
SB  - IM
MH  - Adult
MH  - Diabetes Mellitus, Type 2/*diagnosis
MH  - Female
MH  - Fibroblast Growth Factors/*blood
MH  - Humans
MH  - *Insulin Resistance
MH  - Male
MH  - Medical History Taking
MH  - Middle Aged
MH  - Prediabetic State/blood/*diagnosis
MH  - Prognosis
OTO - NOTNLM
OT  - body mass index
OT  - fibroblast growth factor 21
OT  - first-degree relatives
OT  - history
OT  - obesity
OT  - type 2 diabetes mellitus
EDAT- 2016/02/18 06:00
MHDA- 2017/04/08 06:00
CRDT- 2016/02/18 06:00
PHST- 2015/04/06 00:00 [received]
PHST- 2015/05/27 00:00 [accepted]
PHST- 2015/05/19 00:00 [revised]
PHST- 2016/02/18 06:00 [entrez]
PHST- 2016/02/18 06:00 [pubmed]
PHST- 2017/04/08 06:00 [medline]
AID - VM/OJS/J/41686 [pii]
AID - 10.5603/EP.a2016.0016 [doi]
PST - ppublish
SO  - Endokrynol Pol. 2016;67(3):260-4. doi: 10.5603/EP.a2016.0016. Epub 2016 Feb 17.